对PLA和PCL微粒的比较分析,用于水友性和疏水性药物
Subrat Kumar Panigrahi1, Sougat Das1, Saptarshi Majumdar1
1Department of Chemical Engineering, Indian Institute of Technology Hyderabad, Hyderabad, India.
Journal of microencapsulation
|November 5, 2024
概括
聚乳酸 (PLA) 和聚烯酸 (PCL) 有效地微封装抗光眼瘤药物. 药物释放概况和封装效率得到了优化,显示了影响药物输送的显著药物聚合物相互作用.
科学领域:
- 生物材料科学 生物材料科学
- 制药技术 制药技术 制药技术
- 药物输送系统 药物输送系统
背景情况:
- 青光眼的治疗往往需要持续的药物输送来控制眼内压力.
- 微封装提供了一个有前途的策略,用于控制释放抗白内障药物.
- 聚乳酸 (PLA) 和聚烯酸 (PCL) 是可生物降解的聚合物,经常被用于药物输送应用.
研究的目的:
- 调查PLA和PCL适合于微封装水友性和疏水性抗光眼药物的适用性.
- 分析含有药物的微粒的特性,包括大小,药物聚合物相互作用和释放特征.
- 确定开发的微粒子配方的封装效率和药物载荷能力.
主要方法:
- 基于乳液的溶剂蒸发技术用于微粒制备.
- 光学显微镜和动态光散射 (DLS) 用于粒子大小分析.
- 福里埃转换红外/减弱总反射 (FTIR/ATR) 谱学和DLS被用来研究药物-聚合物相互作用.
- 为了评估药物释放动力学,进行了体外药物释放研究.
主要成果:
- 球形微粒成功地制造出基于PCL的配方,尺寸为94±6.9μm,基于PLA的配方,尺寸为100±3.74μm.
- 实现了高封装效率 (高达95%的PLA,97%的PCL) 和药物负载 (高达2.84%的PLA,2.91%的PCL).
- 药物释放研究表明,药物在大约32天内完全释放,DLS表明水力动力半径增加与增强的封装相关.
结论:
- PLA和PCL是有效的聚合物用于抗光眼瘤药物的微封装,提供受控释放配置文件.
- 药物聚合物相互作用显著影响封装效率和释放动力学,以及关键的实验参数.
- 药物和聚合物性质的选择是优化基于微粒的药物输送系统用于玻璃眼治疗的关键因素.
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