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Jonathan R Weir-McCall¹, Catherine A Fitton¹, Stephen J Gandy¹

¹From the School of Clinical Medicine, University of Cambridge, Cambridge, UK (J.R.W.M.); Department of Radiology, Royal Papworth Hospital, Cambridge, UK (J.R.W.M.); Division of Cardiovascular Research, School of Medicine, University of Dundee, Ninewells Hospital, Dundee, DD1 9SY, UK (C.A.F., J.G.H., J.J.F.B.); NHS Tayside Medical Physics, Ninewells Hospital, Dundee, UK (S.J.G.); Stroke Department, NHS Tayside, Dundee, UK (M.L.); and The University of Queensland, Brisbane, Australia (R.L.).

|November 5, 2024

概括

左心室质量 (LVM) 在低至中等风险的男性和女性中不同预测心血管事件. 增加的LVM是男性的风险标志物,而LVM与体积的比率是女性的关键.

科学领域:

心脏病学心脏病学
心血管成像 - 心血管成像
预防性心脏病学预防性心脏病学

背景情况:

左心室质量 (LVM) 是已知的心血管风险标志物.
低至中等风险人群的长期随访数据有限.
心脏MRI可以评估LVM和心脏重塑模式.

研究的目的:

调查LVM和心血管结果之间的性别特异性关联.
为了评估心脏MRI测量的LVM在10年心血管疾病 (CVD) 风险<20%的个体中.
根据心脏结构确定心血管疾病事件的差异预测因子.

主要方法:

对1528名40岁以上的志愿者进行前性研究,他们的10年心血管疾病风险低于20%,B型尿素水平升高.
用心脏MRI测量体表面积和LVM与体积比率指数的LVM.
国家电子健康记录被用于心血管事件的中位数10年的随访; 考克斯比例危险模型被应用.

主要成果:

在女性中,LVM与体积的比率预测了心血管事件 (HR,2.3;95% CI:1.1,4.9),但LVM没有.
在男性中,增加的LVM预测了心血管事件 (HR,3.2;95%CI:1.5,7.0),但LVM与体积的比率没有.
根据性别,LVM的相关性有所不同:在女性中,LVM与年龄,血压,吸烟和胆固醇相关;在男性中,与年龄和血压相关.

结论:

性别特定的心脏重塑模式预测低至中等风险个体没有建立的心血管疾病的心血管事件.
增加的LVM是男性心血管事件的重要预测因素.
LVM与体积的比率是女性心血管事件的重要预测指标.

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