用CT指导的同轴肺活检:核心数量和与并发症的关联
Charissa R Kim1, Mehmet Ali Sari1, Elena Grimaldi1
1From the Departments of Radiology (C.R.K., M.A.S., E.G., A.B., O.R.B.) and Pathology (P.A.V.), Beth Israel Deaconess Medical Center, 1 Deaconess Rd, Boston, MA 02215.
Radiology
|November 5, 2024
概括
在CT指导的癌症肺活检中获得更多组织样本不会增加肺胸炎或出血等并发症的风险. 这一发现支持了目前用于肺癌诊断和基因组分析的实践.
科学领域:
- 放射学 放射学是一门学科.
- 肺部病理学 肺部病理学
- 在瘤学瘤学.
背景情况:
- 通过皮肤CT引导的肺核心针活检是诊断肺部疾病的标准,安全的程序.
- 肺癌管理的进步需要更大的组织样本来进行全面的基因组分析.
- 当前的协议可能需要重新评估关于每次活检获得的样本数量的情况.
研究的目的:
- 调查CT指导肺活检中获得的核心样本数量与术后并发症发生率之间的关联.
- 为了确定增加活检产量是否会影响疑似初级肺癌病例的患者安全.
主要方法:
- 对827名患者进行皮肤CT导向的同轴肺核针活检以怀疑肺癌的回顾性分析.
- 收集的数据包括患者人口统计,病变特征和获得的活检样本数量.
- 术后并发症 (肺胸,胸管放置,出血,血) 系统地记录并使用多变量逻辑回归来分析.
主要成果:
- 在获得的核心样本数量和肺胸部发生 (P=.81),胸管放置 (P=.26),周围出血 (P=.63) 或血 (P=.60) 发生之间没有发现统计学意义上的关联.
- 肺胸发生在20.7%的患者中,胸管安置发生在3.9%的患者中,出血发生在42.7%的患者中,血发生在2.4%的患者中.
- 获得的样本的中位数为四个,范围为一到十二个.
结论:
- 在疑似肺癌的皮肤CT导向同轴肺活检中获得的核心活检样本的数量与术后并发症的风险增加无关.
- 这些发现支持在不影响患者安全的情况下获得足够的组织进行基因组分析.
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