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相关概念视频

Olfactory Receptors: Location and Structure01:03

Olfactory Receptors: Location and Structure

8.8K
The process of olfaction, also known as the sense of smell, is a sophisticated chemical response system. The specialized sensory neurons that facilitate this process, known as olfactory receptor neurons, are situated in an upper segment of the nasal cavity, known as the olfactory epithelium. Olfactory sensory neurons are bipolar, with their dendrites extending from the epithelium's apex into the mucus that lines the nasal cavity. Airborne molecules, when inhaled, traverse the olfactory...
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Olfaction01:25

Olfaction

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The sense of smell is achieved through the activities of the olfactory system. It starts when an airborne odorant enters the nasal cavity and reaches olfactory epithelium (OE). The OE is protected by a thin layer of mucus, which also serves the purpose of dissolving more complex compounds into simpler chemical odorants. The size of the OE and the density of sensory neurons varies among species; in humans, the OE is only about 9-10 cm2.
The olfactory receptors are embedded in the cilia of the...
44.2K
Physiology of Smell and Olfactory Pathway01:20

Physiology of Smell and Olfactory Pathway

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Humans detect odors with the help of specialized cells located in the upper part of the nasal cavity, called olfactory receptor neurons (ORNs). ORNs possess hair-like structures called cilia, which are receptive to sensations from the inhaled air. When an odorant molecule binds to a specific receptor on the cell of the cilia, it leads to a series of events that ultimately cause the ORN to send electrical signals to the olfactory bulb in the brain through the olfactory nerves.
The olfactory...
8.1K

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相关实验视频

Updated: Jun 8, 2025

Olfactory Neurons Obtained through Nasal Biopsy Combined with Laser-Capture Microdissection: A Potential Approach to Study Treatment Response in Mental Disorders
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Olfactory Neurons Obtained through Nasal Biopsy Combined with Laser-Capture Microdissection: A Potential Approach to Study Treatment Response in Mental Disorders

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嗅觉发育和功能障碍:微质的参与

Sarah J Meller1,2,3, Charles A Greer1,2,3

  • 1Departments of Neuroscience, Yale University School of Medicine, New Haven, Connecticut, United States.

Physiology (Bethesda, Md.)
|November 5, 2024
PubMed
概括
此摘要是机器生成的。

微质细胞,大脑的免疫细胞,可能在各种疾病的嗅觉缺陷中发挥关键作用. 它们在免疫反应中的参与可能会影响嗅觉系统的发育和功能.

关键词:
发展发展发展发展发展.疾病 疾病 疾病 疾病免疫系统 免疫系统微质细胞中的微质细胞嗅觉 嗅觉是一种嗅觉.

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Isolation of Cortical Microglia with Preserved Immunophenotype and Functionality From Murine Neonates
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Isolation of Cortical Microglia with Preserved Immunophenotype and Functionality From Murine Neonates

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Immunofluorescence Staining Using IBA1 and TMEM119 for Microglial Density, Morphology and Peripheral Myeloid Cell Infiltration Analysis in Mouse Brain
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Immunofluorescence Staining Using IBA1 and TMEM119 for Microglial Density, Morphology and Peripheral Myeloid Cell Infiltration Analysis in Mouse Brain

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相关实验视频

Last Updated: Jun 8, 2025

Olfactory Neurons Obtained through Nasal Biopsy Combined with Laser-Capture Microdissection: A Potential Approach to Study Treatment Response in Mental Disorders
08:33

Olfactory Neurons Obtained through Nasal Biopsy Combined with Laser-Capture Microdissection: A Potential Approach to Study Treatment Response in Mental Disorders

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Isolation of Cortical Microglia with Preserved Immunophenotype and Functionality From Murine Neonates
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Isolation of Cortical Microglia with Preserved Immunophenotype and Functionality From Murine Neonates

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Immunofluorescence Staining Using IBA1 and TMEM119 for Microglial Density, Morphology and Peripheral Myeloid Cell Infiltration Analysis in Mouse Brain
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Immunofluorescence Staining Using IBA1 and TMEM119 for Microglial Density, Morphology and Peripheral Myeloid Cell Infiltration Analysis in Mouse Brain

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科学领域:

  • 神经科学是一个神经科学.
  • 免疫学 免疫学 免疫学
  • 眼科医生 眼科 眼科

背景情况:

  • 嗅觉缺陷在神经,神经发育,精神病和病毒性疾病中很常见.
  • 微质是大脑免疫反应和恒温的核心.
  • 嗅觉系统的独特脆弱性和发育特征需要研究微质的作用.

研究的目的:

  • 探索微质在嗅觉发育中的潜在参与.
  • 研究微质在与疾病相关的嗅觉损失中的作用.

主要方法:

  • 对微质细胞,嗅觉系统发育和与疾病相关的嗅觉损失的现有文献的审查.
  • 分析微质免疫反应可能影响嗅觉神经发生和神经元迁移的机制.

主要成果:

  • 微质介导的免疫反应是一种潜在的共同特征,是各种疾病中嗅觉损失的基础.
  • 发育期间的微质活动可能会显著影响嗅觉系统的脆弱性和可塑性.

结论:

  • 微质细胞与嗅觉系统的发展和病理学有关.
  • 了解微质干涉为嗅觉功能障碍提供了潜在的治疗点.