链球菌后的急性球隆骨炎与22F肺炎球菌性细菌性病.
Hinako Itagaki1, Yoshitaka Watanabe1, Naomi Yagi1
1Children's Medical Center, Showa University Northern Yokohama Hospital, 35-1 Chigasaki Chuo, Tsuzuki-Ku, Yokohama, 225-8503, Japan.
Pediatric nephrology (Berlin, Germany)
|November 5, 2024
概括
在接种PCV13疫苗的儿童中,发生了一种罕见的链球菌后急性球球膜炎 (PSAGN) 病例,与疫苗未涵盖的肺炎球菌血清型有关. 这凸显了在患有PSAGN的儿童中检测非疫苗血清型的必要性.
科学领域:
- 儿科 儿科 儿科
- 传染性疾病 传染性疾病
- 腎臟病學 (nephrology) 是一種醫學專業.
背景情况:
- 肺炎球菌疫苗 (PCV13) 已被广泛使用,减少了肺炎球菌感染和相关并发症的报道,如后链球菌急性球球膜炎 (PSAGN).
- 通常PSAGN与Streptococcus pyogenes有关,但肺炎球菌感染也可以引发这种情况.
研究的目的:
- 报告PSAGN病例和由PCV13疫苗中不包括的血清型引起的同时发生的肺炎球菌病.
- 强调在PSAGN病因学中考虑非疫苗肺炎球菌血清型的重要性.
主要方法:
- 一个用PCV13接种的5岁男孩出现了发烧和出血症.
- 诊断工作包括喉抽样以检测 estreptococcal 抗原,血清肌素,抗 streptolysin O,C3 水平和血培养.
- 治疗涉及静脉注射塞夫特里亚克松10天.
主要成果:
- 该患者被诊断患有PSAGN和肺炎,血液培养物识别了Streptococcus pneumoniae血清型22F,该血清型不属于PCV13.
- 在治疗后,患者的功能,肺炎和细菌血症有所改善.
结论:
- 诊断为PSAGN的儿童应对潜在的肺炎球菌血症进行评估.
- 这种评估应包括检测目前疫苗未涵盖的肺炎球菌血清型,例如PCV13.
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