m6Am5CRNA

Oliver Chukwuma Orji1,2, Joseph Stones1, Seema Rajani3

  • 1Division of Cells, Organisms and Molecular Genetics, School of Life Sciences, University of Nottingham, Nottingham, NG7 2UH, UK.

Molecular neurobiology
|November 5, 2024
PubMed
概括

N6腺 (m6A) 和C5细胞 (m5C) 的RNA甲基化系统相互作用,揭示了跨调节的反循环. 这些相互作用影响细胞过程,蛋白质组反应和大脑疾病机制.

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Master Transcription Regulators02:23

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Regulation of Expression Occurs at Multiple Steps02:24

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Regulated mRNA Transport02:22

Regulated mRNA Transport

In eukaryotes, transcription and translation are compartmentalized; an mRNA is first synthesized in the nucleus and then selectively transported to the cytoplasm for protein synthesis. Before transport, a pre-mRNA undergoes several steps of post-transcriptional modifications including splicing, 5' capping, and the addition of a poly-adenine tail. Various proteins bind to the pre-mRNA during these modifications. The mRNA transport takes place with the help of multiple proteins playing...
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