覆盖层是古生物中多样化和丰富的细胞表面层
Sofia Medvedeva1, Guillaume Borrel1, Simonetta Gribaldo1
1Institut Pasteur, Université Paris Cité, Microbiology Department, Evolutionary Biology of the Microbial Cell, 25 rue du dr Roux, 75015, Paris, France.
The ISME journal
|November 5, 2024
概括
古代生物拥有多种不同的形成蛋白质 (SH蛋白质),对细胞结构和相互作用至关重要. 感染这些古细胞的病毒可能会使用类似SH的蛋白质在溶解过程中离开宿主细胞.
科学领域:
- 微生物学 微生物学
- 结构生物学 结构生物学
- 进化生物学 进化生物学
背景情况:
- Prokaryotic 细胞,包括 Archaea,利用保护性的外层,如 S 层和,以求生存和相互作用.
- 由粉样蛋白组成的古老被特定物种特征化,但其更广泛的多样性和功能仍未得到充分探索.
研究的目的:
- 为了进行一个全面的基因组调查的形成蛋白质 (SH蛋白质) 跨越古老的血统.
- 研究SH蛋白质的结构多样性,进化动态和潜在作用,包括它们与病毒的相互作用.
- 识别与覆盖骨质相关的病毒蛋白质,并提出新的病毒退出机制.
主要方法:
- 全基因组对形成蛋白 (SH蛋白) 基因的调查.
- 多种SH蛋白和病毒SH样蛋白的结构建模.
- 遗传学分析以了解进化关系和水平基因转移.
- 病毒OTUs (vOTUs) 的生物信息识别与覆盖古生物相关.
主要成果:
- 确定了各种各样的SH蛋白质,表明TACK超族成员和ANME-1古物中存在.
- SH蛋白表现出多种多样的域安排,表明在细胞结构,相互作用和潜在的合成中具有多功能作用.
- 在感染覆盖骨干的病毒中发现病毒SH类蛋白质,具有宿主覆盖相互作用的潜力和一种新的溶解驱动的退出策略.
结论:
- 考古外比以前所知的更为多样化,在社区内具有显著的SH蛋白的进化交换.
- 病毒SH类蛋白质代表了一种新型的病毒效应因子,对宿主病毒相互作用和病毒复制周期有影响.
- 这项研究扩大了我们对考古外多样性,进化及其对微生物社区结构和动态的影响的理解.
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