胸部CT特征和Omicron变种肺炎患者的危险因素:一个多中心追溯临床研究
Yinghao Yang1, Ying Xie1, Huili Huang1
1Department of Infectious Diseases, Changzheng Hospital, Naval Medical University, Shanghai, China.
Journal of infection in developing countries
|November 5, 2024
概括
高龄,缺乏接种疫苗和特定的并发病增加了在Omicron BA.5波期间COVID-19肺炎的风险. 识别发烧和低淋巴细胞高风险个体有助于早期CT查严重急性呼吸系统综合征冠状病毒-2 (SARS-CoV-2).
科学领域:
- 传染性疾病 传染性疾病
- 放射学 放射学是一门学科.
- 公共卫生 公共卫生
背景情况:
- 在政策变化之后,严重急性呼吸综合征冠状病毒-2 (SARS-CoV-2) Omicron变体在中国的广泛传播,需要了解其临床和成像特征.
- 在上海的Omicron BA.5波期间,对临床和肺部计算机断层扫描 (CT) 特征的早期识别对于指导诊断,治疗和预后至关重要.
研究的目的:
- 分析早期BA.5波期间感染SARS-CoV-2 Omicron变种的患者的临床和肺CT成像特征.
- 确定患COVID-19肺炎的风险因素和与预后不佳相关的因素.
主要方法:
- 从上海医院 (2022年3月至6月) 入院的958名患有Omicron变种感染的患者的临床数据和肺部CT成像的回顾性分析.
主要成果:
- 17.64%的患者患有CT确认的肺炎,大多数患者肺部受影响有限 (肺部面积<10%).
- 年龄较大 (≥65岁),未接种疫苗的情况,以及并发性疾病 (慢性肺病,脑血管疾病,脏疾病,阿尔茨海默病) 与预后不佳有关.
- 肺炎的危险因素包括年龄≥65,未接种疫苗状态,持续发烧 (>5天) 和淋巴细胞数量低 (<0.5×10^9/L).
结论:
- 年龄≥65岁,未接种疫苗状态,持续发烧和低淋巴细胞数量是COVID-19肺炎CT查的关键指标.
- 强调疫苗接种对于增强人口对Omicron变种感染的免疫力至关重要.
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