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高血糖增强的中性细胞外细胞陷驱动口腔屏障的粘膜免疫病理

Qian Wang^1,2, Weimin Lin¹, Kexin Lei¹

¹State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, 610041, China.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

|November 5, 2024

概括

2型糖尿病 (T2D) 通过促进中性粒细胞外细胞陷 (NET) 释放,损害了口腔粘膜屏障的完整性. 向NET或中性粒细胞代谢可能为T2D相关的口腔炎症提供新的治疗方法.

科学领域:

免疫学免疫学免疫学
代谢性疾病是一种代谢性疾病.
口腔健康口腔健康

背景情况:

2型糖尿病 (T2D) 危害粘膜平衡,增加炎症易感性.
中性粒细胞在炎症过程中起着至关重要的作用.

研究的目的:

研究中性粒细胞和中性粒细胞外细胞陷 (NETs) 在2型糖尿病口腔粘膜炎症中的作用.
阐明将高血糖症与口腔免疫病理学联系在一起的潜在机制.

主要方法:

检查了T2D患者和小鼠的牙组织,以检查屏障破坏和中性粒细胞透.
评估了NET形成及其对粘膜屏障完整性的影响.
在高血糖条件下研究了中性粒细胞代谢重编程,包括葡萄糖代谢和GLUT1表达.

主要成果:

二型糖尿病患者和小鼠表现出口腔粘膜屏障破坏和炎症.
中性粒细胞透到牙组织并释放NETs,导致屏障损伤.
移除NET可以缓解粘膜屏障的破坏.
牙中性粒细胞经历新陈代谢重编程,通过高血糖症通过GLUT1增加葡萄糖吸收和糖解.
在T2D患者中,升高的NET水平与疾病严重程度相关.

结论:

在T2D中高血糖会改变中性粒细胞的免疫代谢,导致NET形成和口腔粘膜免疫病理的增加.
NETs是T2D个体口腔粘膜屏障破坏的关键媒介.
针对中性粒细胞代谢重编程和NET形成,为T2D相关的口腔健康问题提供了潜在的治疗策略.

关键词:

葡萄糖输送器 1 葡萄糖输送器葡萄糖溶解是什么过高血糖症 (hyperglycemia) 是一种中性粒细胞中性粒细胞.口腔粘膜免疫的免疫力 2 型糖尿病 2 型糖尿病

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