APOE ε4和与认知功能相关的饮食模式:系统性评论的总体综述
Thomas J Urich1, Amaryllis A Tsiknia2, Nada Ali1
1Department of Medicine, University of Southern California, Los Angeles, CA 90033, United States.
Nutrition reviews
|November 5, 2024
概括
饮食干预措施对APOE ε4载体的有效性有限,除了地中海饮食. 需要对中年,具有APOE ε4基因的认知健康个体进行更多研究.
科学领域:
- 神经科学是一个神经科学.
- 遗传学 遗传学是一种遗传学.
- 营养科学 营养科学
背景情况:
- Apolipoprotein ε4 (APOE ε4) 基因是晚发性阿尔茨海默氏症的重要遗传风险因素.
- APOE ε4 状态可能会影响饮食如何影响认知功能.
研究的目的:
- 进行系统审查的总体审查.
- 根据APOE ε4状态评估饮食干预对认知和脑成像结果的影响.
主要方法:
- 在PubMed,EMBASE,Web of Science和Scopus中搜索到2023年3月.
- 包括6项系统性审查 (RCT,观察性研究) 的50-93岁的个人.
- 两位审稿人使用AMSTAR 2提取数据并评估质量.
主要成果:
- 由于方法上的局限性,观察性研究和临床试验的结果是不确定的.
- 在老年APOE ε4载体中,饮食干预措施 (质饮食,营养保健品,补充剂) 一般是无效的.
- 地中海饮食显示出潜在的益处;考虑了APOE ε4载体反应的生物机制.
结论:
- 确定了文献上的差距,特别是在中年,认知健康的APOE ε4载体中.
- 强调需要研究评估饮食干预措施在这个特定的人口.
- 建议新的试验设计用于未来的研究.
相关概念视频
01:26Alzheimer's Disease: Overview
456
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
456
01:30Cognitive Development During Adulthood
72
Cognitive development continues throughout adulthood, undergoing significant shifts across early, middle, and late stages. Individual transition occurs from adolescent idealism to pragmatic and adaptable thinking in early adulthood. During this period, individuals learn to integrate personal beliefs with the recognition that other perspectives are equally valid. Exposure to the complexities of modern society, diverse experiences, and higher education contribute to this adaptive thought process,...
72