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Hlib Razumkov1,2, Zixuan Jiang1,2, Kheewoong Baek3,4

  • 1Department of Chemistry, Stanford School of Humanities and Sciences, Stanford University, Stanford, California 94305, United States.

Journal of the American Chemical Society
|November 5, 2024
PubMed
概括

研究人员开发了一种对谷胺分子的模块化合成方法,确定了素激酶1α (CK1α) 和微型蛋白激酶1 (WEE1) 的新降解剂. 这种方法使选择性蛋白质降解剂能够用于治疗.

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Covalently Linked Protein Regulators02:04

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Proteins can undergo many types of post-translational modifications, often in response to changes in their environment. These modifications play an important role in the function and stability of these proteins. Covalently linked molecules include functional groups, such as methyl, acetyl, and phosphate groups, and also small proteins, such as ubiquitin. There are around 200 different types of covalent regulators that have been identified.
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