Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

T Cell Activation and Clonal Selection01:22

T Cell Activation and Clonal Selection

672
T cells are integral to our adaptive immune system, recognizing and effectively responding to foreign antigens. T cell activation and clonal selection are pivotal in orchestrating this immune response. This article elucidates these mechanisms, detailing the roles of cluster of differentiation (CD) markers, major histocompatibility complex (MHC) molecules, costimulatory signals, and the process of clonal selection.
Naive T cells that have not yet encountered an antigen express two primary CD...
672
Intracellular Signaling Affects Focal Adhesions01:17

Intracellular Signaling Affects Focal Adhesions

2.6K
Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...
2.6K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

H3K27me3 chromatin heterogeneity reveals variable cell responses to estrogen and endocrine treatment.

bioRxiv : the preprint server for biology·2025
Same author

Hyaluronan Ameliorates Viral Pneumonia in Mice and Humans by Inhibiting Transcription Factor E2F1.

American journal of respiratory cell and molecular biology·2025
Same author

L-type calcium channel blockers at therapeutic concentrations are not linked to CRAC channels and heart failure.

Clinical and experimental hypertension (New York, N.Y. : 1993)·2025
Same author

CRAC channel activity pulsates during cytosolic Ca<sup>2+</sup> oscillations.

The Journal of biological chemistry·2025
Same author

Plasma Membrane Ca<sup>2+</sup> ATPase Activity Enables Sustained Store-operated Ca<sup>2+</sup> Entry in the Absence of a Bulk Cytosolic Ca<sup>2+</sup> Rise.

Function (Oxford, England)·2024
Same author

Homeostatic coordination of cellular phosphate uptake and efflux requires an organelle-based receptor for the inositol pyrophosphate IP8.

Cell reports·2024
Same journal

Excess muscle plasma membrane leak disrupts extracellular matrix content and shifts macrophage-mediated muscle repair.

JCI insight·2026
Same journal

A Validated, Modifiable Proteomic Score from the EXSCEL Trial Predicts Cardiovascular Events in Diabetes.

JCI insight·2026
Same journal

Proteomic profiling of plasma extracellular vesicles reveals a therapeutically targetable liver-heart axis in cardiac transplantation.

JCI insight·2026
Same journal

Early cell-autonomous and niche-mediated epithelial response to influenza infection in primary alveolar organoids.

JCI insight·2026
Same journal

BCG vaccination elicits protection against Mtb infection mediated by two phases of T cell immunity.

JCI insight·2026
Same journal

Reduced peroxisomal function increases insulin secretion, promotes insulin oxidation, and impairs β cell maturity.

JCI insight·2026
查看所有相关文章

相关实验视频

Updated: Jun 8, 2025

Qualitative and Quantitative Analysis of the Immune Synapse in the Human System Using Imaging Flow Cytometry
08:35

Qualitative and Quantitative Analysis of the Immune Synapse in the Human System Using Imaging Flow Cytometry

Published on: January 7, 2019

11.5K

弗洛蒂林-2抑制T细胞抗原的敏感性和功能.

Sookjin Moon1, Fei Zhao1, Mohammad N Uddin1

  • 1Immunity, Inflammation and Disease Laboratory and.

JCI insight
|November 5, 2024
PubMed
概括
此摘要是机器生成的。

移除flotillin-2 (Flot2) 蛋白质可以提高T细胞对抗原的敏感性. 这促进了T细胞的反应,改善免疫力,通过调节T细胞受体聚类来减少瘤生长.

关键词:
免疫学 免疫学 免疫学脂质漂泊船是指脂质漂泊船.T细胞受体受体的 T 细胞受体.在T细胞,T细胞.

更多相关视频

Ex vivo Imaging of T Cells in Murine Lymph Node Slices with Widefield and Confocal Microscopes
09:45

Ex vivo Imaging of T Cells in Murine Lymph Node Slices with Widefield and Confocal Microscopes

Published on: July 15, 2011

16.9K
Author Spotlight: Development of a Method for Identifying Small Molecular Antagonists of &#946;2 Integrin Activation
04:15

Author Spotlight: Development of a Method for Identifying Small Molecular Antagonists of β2 Integrin Activation

Published on: February 2, 2024

1.7K

相关实验视频

Last Updated: Jun 8, 2025

Qualitative and Quantitative Analysis of the Immune Synapse in the Human System Using Imaging Flow Cytometry
08:35

Qualitative and Quantitative Analysis of the Immune Synapse in the Human System Using Imaging Flow Cytometry

Published on: January 7, 2019

11.5K
Ex vivo Imaging of T Cells in Murine Lymph Node Slices with Widefield and Confocal Microscopes
09:45

Ex vivo Imaging of T Cells in Murine Lymph Node Slices with Widefield and Confocal Microscopes

Published on: July 15, 2011

16.9K
Author Spotlight: Development of a Method for Identifying Small Molecular Antagonists of &#946;2 Integrin Activation
04:15

Author Spotlight: Development of a Method for Identifying Small Molecular Antagonists of β2 Integrin Activation

Published on: February 2, 2024

1.7K

科学领域:

  • 免疫学 免疫学 免疫学
  • 细胞生物学 细胞生物学
  • 分子生物学分子生物学

背景情况:

  • T细胞受体 (TCR) 的参与对T细胞反应至关重要.
  • 在血中通过TCR介导的激活的调节尚未完全理解.

研究的目的:

  • 为了研究flotillin-2 (Flot2) 在调节T细胞激活中的作用.
  • 确定Flot2如何影响T细胞对弱TCR刺激的敏感性.

主要方法:

  • 生成的T细胞特异性Flot2缺陷小鼠.
  • 分析了T细胞信号传递,增殖和效应器功能.
  • 使用单细胞RNA-Seq和超分辨率显微镜.

主要成果:

  • 机组2缺乏增加了T细胞抗原敏感性和TCR信号传递.
  • 在Flot2-null小鼠中,瘤生长减少,免疫力增强.
  • 飞2切除导致天真CD4+T细胞TCR纳米团形成的增加.

结论:

  • 弗洛蒂林-2 负面调节 T 细胞对弱 TCR 刺激的敏感性.
  • 通过影响表面TCR聚类,Flot2调节T细胞功能.
  • 准Flot2可以改善T细胞在癌症和慢性感染中的反应性.