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高致病性禽流感A ((H5N1) 病毒感染猫,韩国,2023年

Yong-Myung Kang, Gyeong-Beom Heo, Se-Hee An

Emerging infectious diseases

|November 5, 2024

概括

高致病性禽流感 (HPAI) A(H5N1) 在韩国通过受污染的生肉感染了猫. 该病毒显示了哺乳动物适应突变,在猫科动物中引起严重疾病和死亡.

科学领域:

兽医病毒学兽医病毒学
动物传播疾病动物传播疾病
一个健康一个健康

背景情况:

高致病性禽流感 (HPAI) A(H5N1) 对家禽构成重大威胁,并可能蔓延到哺乳动物.
最近的疫情凸显了HPAI病毒的新传播途径和宿主适应性的潜力.

研究的目的:

为了调查韩国首尔流浪猫中HPAI爆发的情况.
为了确定感染源并描述涉及的HPAI A(H5N1) 病毒.
评估循环病毒菌株的哺乳动物适应潜力.

主要方法:

在两个猫舍中对HPAI病例的流行病学调查.
从受感染的猫和可疑的食物来源进行病毒隔离和全基因组测序.
遗传学分析以确定病毒的起源和与其他菌株的关系.
对受影响的猫进行尸检和本病理学分析.

主要成果:

在猫和疑似生肉中发现了HPAI A ((H5N1) 类别2.3.4.4b.
该病毒的基因组合与2022年11月的韩国菌株相似.
来自猫的分离物在聚合酶基本2基因中具有突变 (E627K或D701N),表明哺乳动物适应.
尸检结果显示,猫的系统性疾病和广泛的病毒传播.

结论:

摄入受污染的生肉是猫中HPAI感染的可能来源.
哺乳动物适应突变的存在表明,HPAI A ((H5N1) 在非鸟类宿主中发生了令人担忧的演变.
这一事件突显了动物传播的风险,并强调了监测家禽和食品来源的高危禽流感的重要性.

关键词:

这是一种H5N1流感.韩国韩国韩国韩国猫猫猫在线观看高致病性禽流感是一种高度致病性禽流感.流感流感流感流感流感原料子肉生子肉病毒病毒病毒病毒.动物病是动物病.

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