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对新出现的有机酸盐的内分泌干扰作用进行全面评估
Quan Zhang1, Liuqing Yang1, Huiyun Wang1
1College of Environment, Zhejiang University of Technology, Hangzhou, Zhejiang 310032, China.
Environment international
|November 5, 2024
概括
新兴的有机酸盐 (OPEs) 具有显著的内分泌干扰风险. 副基基酸盐 (para-OH-TPHP) 对多种激素受体表现出强烈的对抗作用,影响了斑马鱼的发育和繁殖,这表明健康问题很大.
科学领域:
- 环境化学环境化学
- 毒理学 毒理学 毒理学
- 内分泌学 在内分泌学.
背景情况:
- 有机酸盐 (OPEs) 在环境中被广泛使用和检测到.
- 人们越来越担心它们的潜在内分泌干扰作用和相关的健康风险.
研究的目的:
- 综合评估六种新兴OPE的内分泌干扰性质.
- 评估它们对激素受体,类固醇生成以及斑马鱼发育和行为的影响.
主要方法:
- 对激素受体 (ERα,TRβ,GR,MR) 的对抗作用进行了六种OPE (五种aryl-OPE和一种alkyl-OPE) 的测试.
- 在斑马鱼中对类固醇生成基因表达 (cyp19,cyp11b2,cyp11a1) 的评估影响.
- 评估了斑马鱼胚胎和成人的发育毒性和HPG轴基因表达.
主要成果:
- 所有测试的烯-OPEs都对激素受体表现出对抗作用;帕拉-OH-TPHP是最强的.
- 帕拉-OH-TPHP抑制了雌激素和皮质醇合成基因;几个OPE降低了关键激素合成酶的调节.
- OPEs导致斑马鱼的发育不良,游泳异常,并影响HPG轴基因和生殖行为;para-OH-TPHP显示最高风险.
结论:
- 新兴的OPE,特别是para-OH-TPHP,表现出显著的内分泌干扰作用.
- 这些化合物影响激素受体功能,类固醇生成和发育.
- 迫切需要进一步的研究来评估OPE暴露对健康的影响.
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