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神经元生成和保护作用激活由 ангиотензин 1-7 在星球细胞-神经元相互作用中

Gabriel Alberto de Carvalho Barbosa¹, Marina Prado Rubinho¹, Milton Kennedy Aquino-Júnior¹

¹Department of Biochemistry, Federal University of Alfenas, Alfenas, Minas Gerais, Brazil.

|November 5, 2024

概括

ангиотензин-(1-7) 调节星细胞,促进神经营养因子和神经保护. 这与 ангиотензин II 相反,突出显示中枢神经系统.

科学领域:

神经科学是一个神经科学.
内分泌学在内分泌学.
细胞生物学细胞生物学

背景情况:

氨酸-血管素系统 (RAS) 在神经系统疾病中起作用.
星球细胞表达RAS的功能性受体 - - ангиотензин-(1-7) 和 ангиотензинII.
了解中枢神经系统 (CNS) 中的星细胞-神经元相互作用至关重要.

研究的目的:

调查RAS的作用,特别是 ангиотензин-(1-7) 和 ангиотензинII,在天体细胞衍生的热因子分泌中的作用.
为了确定这些因素对海马神经元的影响.
阐明RAS在神经元-星细胞通信中的生化机制.

主要方法:

使用了大鼠海马的天体细胞和神经元的初级培养.
用 ангиотензин-(1-7) 和 ангиотензинII治疗星球细胞.
分析天体细胞调节,包括质纤维酸蛋白 (GFAP) 表达.
从经过处理的天体细胞中制备条件介质.
对神经营养因子分泌和神经保护作用对刺激毒性的评估.

主要成果:

ангиотензин-(1-7) 治疗诱导了星球细胞中的反应性星化,由增加的GFAP表达体现出来.
来自受 ангиотензин-(1-7) 治疗的天体细胞的条件介质促进了神经营养因子的分泌.
这种有条件的介质表明神经保护作用对谷氨酸激素激发性毒性.
ангиотензин II 并没有诱导类似的有益作用,并加剧了对大脑RAS的有害作用.

结论:

ангиотензин-(1-7) 调节星细胞,增强神经营养因子的分泌,并提供神经保护.
ангиотензин II 对星球细胞表现出不同的作用,可能对大脑RAS有害.
由RAS介导的神经元-星细胞相互作用是中枢神经系统功能不可或缺的组成部分,并提供治疗点.

关键词:

Ang-(17) 的意思是说.星球细胞是星球细胞.神经元-质细胞相互作用反应性星球化是反应性的.雷宁 - ангиотензин 系统

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