青少年患有严重抑郁症和非自杀性自我伤害的皮质形态变化
Xiaonan Pang1, Dongpeng Wu2, Hongping Wang2
1Department of Neurology, The Second Affiliated Hospital of Anhui Medical University, Hefei 230601, China; Department of Psychology and Sleep Medicine, The Second Affiliated Hospital of Anhui Medical University, Hefei 230601, China.
NeuroImage. Clinical
|November 5, 2024
概括
非自杀性自我伤害 (NSSI) 的青少年表现出明显的大脑结构变化,特别是在与情绪调节和认知控制相关的区域,提供了对主要抑郁症 (MDD) 病理生理学的见解.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 神经成像是一种神经成像.
背景情况:
- 非自杀性自我伤害 (NSSI) 在青少年中很普遍,经常与严重抑郁症 (MDD) 一起发生.
- NSSI存在重大风险,包括身体伤害,认知缺陷,以及未来心理障碍和自杀企图的可能性增加.
- 了解NSSI的神经生物学基础对于开发有效的干预措施至关重要.
研究的目的:
- 使用先进的神经成像技术,研究NSSI青少年与健康对照者之间的结构性大脑差异.
- 为了将观察到的神经解剖学变化与临床和心理评估相关联.
主要方法:
- 在44名NSSI患者和44名健康对照人群 (HCs) 上使用基于声素的形态测量 (VBM) 和基于表面的形态测量 (SBM).
- 灰色物质体积 (GMV),皮质厚度 (CT) 和皮质复杂性的比较.
- 使用了两种样本的t测试和与神经心理学尺度相关的发现.
主要成果:
- 在NSSI患者中,左侧胰岛,左侧前带状皮质,左侧皮质,左侧中额头环,以及小脑后叶的GMV增加.
- 在多个左半球区域观察到CT的增加,而在右中额头回中观察到CT的减少.
- 在NSSI患者中发现皮层复杂性降低 (SD降低,下部GI),右中额头回环CT和愤怒之间存在相关性,右上额头回环SD和敌意.
结论:
- NSSI患者在关键区域表现出显著的结构性大脑变化,包括岛皮质,前额皮质和前带皮质.
- 这些发现为了解MDD的背景下NSSI的病理生理学提供了形态基础.
- 该研究突出了NSSI的特定神经解剖学相关物,告知了潜在的治疗点.
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