在荷兰的Listeria monocytogenes的来源归因
Lapo Mughini-Gras1, Julian A Paganini2, Ruoshui Guo2
1Centre for Infectious Disease Control, National Institute for Public Health and the Environment (RIVM), Bilthoven, Netherlands; Institute for Risk Assessment Sciences (IRAS), Utrecht University, Utrecht, Netherlands.
International journal of food microbiology
|November 5, 2024
概括
牛,特别是新鲜的牛肉,是荷兰人类菌病的主要来源,牛排风险增加. 吸烟的鱼也构成风险,而传播的菌病缺乏已知的风险因素.
科学领域:
- 食品安全和公共卫生微生物学
- 基因组流行病学和来源归因
- 动物传染性疾病的传播
背景情况:
- 由Listeria monocytogenes (Lm) 引起的人类菌病,对公共健康造成重大关注.
- 确定主要的食物来源和相关的风险因素对于有效的预防策略至关重要.
- 之前的研究已经探讨了LM来源,但需要综合基因组和流行病学数据的综合分析.
研究的目的:
- 确定不同食物来源对荷兰人群李斯特菌病的相对贡献.
- 为了确定人类Listeria monocytogenes感染的特定源相关风险因素.
- 通过综合基因组和流行病学分析,调查LM的起源和传播途径.
主要方法:
- 来自荷兰的人类病例 (n=756) 和食品/动物来源 (n=950) 的Lm分离物的全基因组测序 (2010-2020年).
- 使用基于核心基因组多部位序列类型 (cgMLST) 的随机森林模型进行源归因分析.
- 贝塔回归分析以确定与牛,和海鲜有关的人类LM感染的风险因素.
主要成果:
- 从人类病例中分离出的LM主要归因于牛 (62.3%), (19.4%) 和海鲜 (16.9%).
- 新鲜的肉类,特别是新鲜的牛肉 (43.7%) 和新鲜的肉 (39.3%),占据了大部分归因的病例.
- 牛排和鱼的消费与来自牛和海鲜的LM感染风险增加有关.
结论:
- 来自牛的Listeria monocytogenes分离物,特别是来自新鲜牛肉的Listeria monocytogenes分离物,是荷兰人类菌病的主要原因.
- 特定的食物消费模式,如牛排和鱼,与从已确定的来源增加的LM感染风险有关.
- 综合基因组和流行病学数据为LM传播提供了宝贵的见解,并为有针对性的公共卫生干预提供了信息.
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