一种取决于饮食的宿主代谢物塑造了肠道微生物群,以防止自身免疫
Margaret Alexander1, Vaibhav Upadhyay2, Rachel Rock3
1Department of Microbiology & Immunology, University of California, San Francisco, San Francisco, CA 94143, USA; Department of Medical Microbiology and Immunology, University of Wisconsin - Madison, Madison, WI 53706, USA.
Cell reports
|November 5, 2024
概括
性饮食 (KD) 通过改变肠道微生物群的新陈代谢来预防自身免疫性疾病. 这个饮食,这个饮食.
科学领域:
- 免疫学 免疫学 免疫学
- 微生物组研究 微生物组研究
- 代谢研究 代谢研究
背景情况:
- 饮食干预措施在控制自身免疫性疾病方面表现有前途.
- 饮食影响自身免疫状况的确切机制,特别是宿主和微生物组的作用,仍然不完全理解.
研究的目的:
- 调查性饮食 (KD) 对自身免疫性疾病的影响,重点关注宿主微生物群相互作用.
- 阐明涉及饮食诱导免疫调节的特定分子介质.
主要方法:
- 使用了多发性硬化症的实验性自身免疫脑膜炎 (EAE) 鼠标模型.
- 接受了性饮食,并补充了β-基酸盐 (βHB).
- 进行了微生物群移植和体外测试,使用Lactobacillus菌株和代谢物.
主要成果:
- 一种性饮食 (KD) 以微生物群依赖的方式拯救了EAE.
- 直接补充β-基酸盐 (βHB) 改善了EAE.
- 由βHB塑造的肠道微生物群提供了保护,特定的Lactobacillus菌株及其代谢物英多尔乳酸盐表现出免疫调节作用.
结论:
- 饮食干预,如KD,通过宿主代谢转变调节肠道微生物群的免疫调节能力.
- β-甲酸 (βHB) 在介导KD对自身免疫反应的保护作用方面发挥着关键作用.
- 考虑饮食,宿主新陈代谢和微生物组的综合性方法对于理解和治疗自身免疫性疾病至关重要.
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