快速步行节奏抵消了静脉血栓栓塞的风险,相当于已确定的单一基因突变
Wenyan Xian1, Yifan Tao2, Chong You3
1School of Public Health and Emergency Management, Southern University of Science and Technology, Shenzhen, China.
Thrombosis and haemostasis
|November 5, 2024
概括
快速的步行节奏显著降低了静脉血栓栓塞 (VTE) 的风险,甚至抵消了遗传倾向. 这种保护作用在一定程度上是由血清白蛋白和囊素C水平介导的.
科学领域:
- 遗传学和心血管健康
- 流行病学和公共卫生.
背景情况:
- 静脉血栓塞栓症 (VTE) 的已确定的遗传风险因素包括原血 (F2) 和V因子Leiden (F5) 基因的突变.
- 虽然步行速度与冠状动脉疾病风险有关,但与VTE的关联仍然未被探索.
研究的目的:
- 调查步行节奏和VTE之间的关联和因果关系.
- 为了比较与步行节奏相关的VTE的人群风险与已确定的孟德尔基因突变.
- 为了确定血液生物标志物是否介导着步行节奏对静脉瘤风险的影响.
主要方法:
- 利用445,261名参与者的英国生物库数据,评估自我报告的步行速度和F2和F5突变的遗传载体状态.
- 采用了考克斯的比例危险模型和双向门德尔随机化 (MR) 分析.
- 使用个人级别数据和GWAS总结统计数据进行调解分析.
主要成果:
- 在12.8年的时间里,确诊了11,155例VTE病例. 缓慢的步行节奏显示了10年的发病率为3.90%,而快速步行节奏为1.32%.
- 携带F5突变的10年VTE发病率为3.62%,而非携带者为1.70%. 快速的步伐降低了F5载体的VTE风险 (p<0.05).
- MR 分析证实了步行节奏和VTE之间的因果逆关系. 血清白蛋白 (ALB) 和囊素C (CYS) 部分调解了这种效应 (8.7-11.7%的调解).
结论:
- 快速的步行节奏为人群提供了对VTE的保护作用,抵消了孟德尔突变带来的风险.
- 有证据表明,快速步行节奏降低了VTE发病率的因果关系.
- 血清ALB和CYS水平被确定为快速步行速度与VTE风险关系中的部分调解者.
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