急性运动可以促进人体外周血液单核细胞的NAD+代谢
David Walzik1, Niklas Joisten2, Alexander Schenk1
1Department of Performance and Health (Sports Medicine), Institute for Sport and Sport Science, TU Dortmund University, Otto-Hahn-Straße 3, 44227 Dortmund, Germany.
Brain, behavior, and immunity
|November 5, 2024
概括
剧烈的运动可以促进人类免疫细胞中的尼古丁胺腺因二核酸 (NAD+) 代谢. 这表明运动可以通过增加外围血液单核细胞 (PBMC) 中的NAD+生物合成来增强免疫功能和适应能力.
科学领域:
- 免疫代谢过程中的免疫代谢.
- 运动生理学 运动生理学
- 衰老研究研究 衰老研究
背景情况:
- 尼古丁胺胺氨基二核酸 (NAD+) 对于能量代谢至关重要,与衰老和疾病相关的水平下降.
- 众所周知,运动可以增加NAD+水平,主要研究的是骨肌肉,但其对免疫细胞的影响不太清楚.
- 运动期间免疫细胞被调动,这表明对它们的NAD+代谢有潜在的影响.
研究的目的:
- 为了研究单次运动会对人类外围血液单核细胞 (PBMCs) 中的NAD+代谢的影响.
- 为了比较高强度间歇训练 (HIIT) 和中等强度持续训练 (MICT) 对PBMC NAD+代谢的影响.
- 探索NAD+救援途径,特别是NAMPT在运动后PBMC中的作用.
主要方法:
- 进行了两个互补的人体试验:一个随机交叉试验 (DRKS00017686) 和一个纵向运动试验 (DRKS00029105).
- 参与者包括年轻成年人 (交叉试验中24人,纵向试验中12人).
- 测量包括基因表达和NAD+代谢酶的蛋白质丰度,细胞内NAD+水平和血清尼古丁胺胺.
主要成果:
- 急性炼,无论是HIIT还是MICT,都显著增加了PBMC中关键的NAD+代谢酶的表达和蛋白质水平.
- 由NAMPT调解的NAD+救援途径被确定为PBMC对运动反应的关键.
- 运动导致细胞内NAD+水平增加,并在PBMC中减少血清尼古丁胺.
结论:
- 急性运动刺激人体PBMC中的NAD+生物合成,突出了身体活动和免疫细胞代谢之间的新联系.
- 这些发现表明对免疫代谢,免疫细胞功能和运动诱导的免疫适应的潜在影响.
- NAD+救援途径在PBMC如何适应急性运动方面发挥着关键作用.
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