DES/O微乳液用于溶解和通过鼻腔给药提供黄素,用于治疗急性喘
Yiwen Liu1, Ruirui Liu2, Qingliang Yang2
1College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014, Zhejiang, China; The First Hospital of Jiaxing, Affiliated Hospital of Jiaxing University, Jiaxing 314001, Zhejiang, China.
这项研究开发了一种新型的油微乳液 (DES/O-ME) 系统中的深度浸泡溶剂 (DES),以改善黄素 (Cur) 输送. 新系统增强了黄素的功效.
科学领域:
- 药理学和药物输送 药理学和药物输送
- 材料科学 材料科学 材料科学
- 纳米技术 纳米技术
背景情况:
- 黄 (Cur) 来自黄,具有广泛的治疗性质,但水溶性和不稳定性差.
- 这些限制显著阻碍了黄素的生物可用性和临床效用.
- 鼻内药物输送提供了一种潜在的途径,可以绕过第一通代谢并增强药物输送到大脑和全身循环.
研究的目的:
- 开发和优化油微乳液 (DES/O-ME) 系统中的深度优化溶剂 (DES),用于鼻内递送黄素.
- 为了提高黄素的可溶性,透性和生物可用性.
- 在过敏性喘模型中评估含有黄素的DES/O-ME系统的治疗疗效.
主要方法:
- 构建和选基于胆化的深度浸泡溶剂 (DES).
- 准备和优化DES/O-ME系统使用伪三次相图和电导率.
- 评估黄素的溶解性,透性,粘膜细胞毒性和系统稳定性.
- 在体中评估过敏喘的小鼠模型中的治疗功效.
主要成果:
- 一个优化的DES/O-ME系统成功地准备好了,具有统一的粒子大小和良好的稳定性.
- DES/O-ME系统显著提高了黄素的可溶性和透性.
- 含有黄素的DES/O-ME显示出良好的粘膜相容性和稳定性.
- 在体内研究表明,在过敏性喘模型中,有前途的治疗效果.
结论:
- 开发的DES/O-ME系统是一个有前途的平台,用于黄素的鼻入输送.
- 这种系统有效地克服了黄素的生物可用性限制.
- 这些发现支持这种新型药物递送系统对黄素的潜在临床应用.
更多相关视频
05:44Novel Methods for Intranasal Administration Under Inhalation Anesthesia to Evaluate Nose-to-Brain Drug Delivery
Published on: November 14, 2018
15:04Modeling and Simulations of Olfactory Drug Delivery with Passive and Active Controls of Nasally Inhaled Pharmaceutical Aerosols
Published on: May 20, 2016
相关概念视频
Inhaled Medications
Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Drug Delivery: Miscellaneous Routes
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
Upper Respiratory Drugs: Antitussives, Expectorants, and Mucolytics
Antitussives include codeine, dextromethorphan (Robitussin), and benzonatate (Tessalon). Codeine and dextromethorphan exert their effects centrally by suppressing the cough reflex center in the medulla. Benzonatate operates peripherally within the respiratory tract by...
Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
Asthma-IV: Diagnostic and Management
Clinical Assessment for Asthma:
This is the first step in diagnosing and managing asthma. It includes:
