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隔离四肢输液作为第一个,第二个或第三个或更晚的线路治疗转移性中转移性黑色素瘤

Aleena Boby¹, Michelle M Dugan², Helana Ghali¹

¹University of South Florida Tampa, University of South Florida Morsani College of Medicine, Tampa, FL, USA.

Cancer control : journal of the Moffitt Cancer Center

|November 5, 2024

概括

隔离四肢输注 (ILI) 有效地治疗过境黑色素瘤转移 (ITM). 虽然ILI显示了作为一线治疗的更高的响应率,但它仍然是一个有价值的治疗选择,即使是接受过先前治疗的患者.

科学领域:

在瘤学瘤学.
手术瘤学手术瘤学
皮肤病学皮肤病学

背景情况:

过境转移 (ITM) 影响10%的黑色素瘤患者.
隔离四肢输液 (ILI) 是不可切割的ITM的标准治疗方法.
在黑色素瘤治疗中,ILI的最佳时间尚未确定.

研究的目的:

根据其治疗线来评估ILI的有效性.
为了比较ILI作为一线,二线或第三线/后线治疗不可切割的ITM.

主要方法:

用ILI治疗的无法切除的ITM患者的回顾性审查.
从2006年到2023年收集的数据.
分析整体响应率 (ORR),完整响应 (CR),无进展生存率 (PFS) 和整体生存率.

主要成果:

分析了130名用ILI治疗的无法切除的ITM患者.
总体响应率 (ORR) 为74%,完整响应率 (CR) 为41%.
第一线ILI显示了较高的ORR (78%) 与第二线 (63%) 和第三线/后一线 (57%) 相比,尽管在统计学上并不显著.

结论:

ILI是不切除黑色素瘤ITM的有效治疗方法,无论之前的治疗方法如何.
一线ILI表明ORR在临床上有意义的改善.
ILI可以成功地被用作晚期黑色素瘤的救援疗法.

关键词:

在ITM黑色素瘤.在过境转移的转移.隔离的四肢输液.隔离的肢体输液在过境的黑色素瘤.发生转移的黑色素瘤.区域化疗是一种区域化疗.治疗治疗的治疗线的治疗.

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