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Updated: Jun 8, 2025

A High-throughput Calcium-flux Assay to Study NMDA-receptors with Sensitivity to Glycine/D-serine and Glutamate
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通过使用药理平衡建模的GluN2A选择性对抗剂对全性NMDA受体调节的评估

James S Lotti1, Jaron Jones2, Jill C Farnsworth2

  • 1University of Montana, United States.

Molecular pharmacology
|November 5, 2024
PubMed
概括

一个新的模型量化了NMDA受体调节器活性,揭示了GluN2A选择性负基调节器 (NAM) 之间的差异. 这有助于通过理解结构-活动关系来设计治疗大脑疾病的新疗法.

关键词:
这就是"Allosterism"的说法.带导入离子通道的离子通道甲基D-酸盐 (NMDA) 是一种电力生理学 电力生理学葡萄糖酸盐受体的受体

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