倡导DoHaD研究优化儿童脏健康
1Division of Pediatric Nephrology, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, 833, Taiwan; College of Medicine, Chang Gung University, Taoyuan, 330, Taiwan; Institute for Translational Research in Biomedicine, Kaohsiung Chang Gung Memorial Hospital, Kaohsiung, 833, Taiwan.
Pediatrics and neonatology
|November 5, 2024
概括
产前风险因素可以通过母胎相互作用来编程后代的病. 本综述探讨了动物模型中的脏编程机制和重编程策略,以预防早期脏疾病.
科学领域:
- 周围生理学 周围生理学
- 腎臟病學 (nephrology) 是一種醫學專業.
- 发展生物学 发展生物学
背景情况:
- 新出现的证据将产前风险因素与子女终身病风险联系起来.
- 由母胎相互作用驱动的脏编程,涉及结构和功能上的改变.
- 健康和疾病的发育起源 (DOHaD) 理论强调了生命早期编程的作用.
研究的目的:
- 审查编程对后代病的影响.
- 为了概述预防病的重编程策略.
- 将研究成果与儿科脏健康的临床应用联系起来.
主要方法:
- 关于脏编程的现有研究的文献综合.
- 对动物模型进行审查,以展示重编程策略.
- 对发育中的母胎界面机制的分析.
主要成果:
- 产前因素启动脏编程,增加晚年疾病的风险.
- 结构和功能性脏变化是关键机制.
- 重编程策略在临床前动物研究中显示出有前途.
结论:
- 了解脏编程对于预防儿童脏疾病至关重要.
- 重编程提供了一个潜在的治疗途径.
- 将动物模型的发现转化为临床实践对于改善儿科脏结果至关重要.
相关概念视频
01:24Renal Tubule and Collecting Duct
818
The renal tubule is divided into three parts: the proximal convoluted tubule (PCT), the Loop of Henle (LOH), and the distal convoluted tubule (DCT).
Proximal Convoluted Tubule (PCT):
The PCT is the initial segment of the renal tubule, extending from the Bowman's capsule that encloses the glomerulus. Its convoluted structure and microvilli-lined cells increase the surface area for reabsorption. The PCT reabsorbs glucose, amino acids, sodium, and water from the filtrate, ensuring essential...
Proximal Convoluted Tubule (PCT):
The PCT is the initial segment of the renal tubule, extending from the Bowman's capsule that encloses the glomerulus. Its convoluted structure and microvilli-lined cells increase the surface area for reabsorption. The PCT reabsorbs glucose, amino acids, sodium, and water from the filtrate, ensuring essential...
818
01:12Internal Anatomy of the Kidney
1.4K
The kidneys are essential organs in the human body, performing a myriad of tasks that maintain homeostasis and overall health.
Anatomical Position and Dimensions
The kidneys are retroperitoneal organs positioned against the posterior abdominal wall on either side of the spine, roughly between the twelfth thoracic and third lumbar vertebrae. Each kidney is typically 10-12 cm long, 5-6 cm wide, and 3-4 cm thick, weighing about 150 grams.
Renal Cortex
The outermost region of the kidney is the...
Anatomical Position and Dimensions
The kidneys are retroperitoneal organs positioned against the posterior abdominal wall on either side of the spine, roughly between the twelfth thoracic and third lumbar vertebrae. Each kidney is typically 10-12 cm long, 5-6 cm wide, and 3-4 cm thick, weighing about 150 grams.
Renal Cortex
The outermost region of the kidney is the...
1.4K
01:11Renal Failure: Dose Adjustments
67
In patients with renal impairment, drugs undergo significant changes in their pharmacokinetics, which require dosage adjustments to ensure safe and effective therapy.
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
67
01:27Dialysis
269
Renal failure occurs when the kidneys lose their ability to filter waste products from the blood effectively. It can be classified into two types: acute renal failure (ARF) and chronic renal failure (CRF).
Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...
Acute kidney injury develops suddenly and can be caused by pre-renal causes (e.g., hypovolemia, shock), intrinsic renal causes (e.g., acute tubular necrosis), or post-renal causes (e.g., urinary obstruction). In contrast, chronic renal failure progresses gradually over time and is often...
269