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相关概念视频

Microtubules in Signaling01:22

Microtubules in Signaling

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The primary cilium, made up of microtubules, acts as antennae on the cell surfaces for relaying external stimuli into the cells. These fine hair-like structures are present, generally one per cell. These are non-motile cilia in a 9+0 microtubules arrangement, where the central pair of microtubules are absent. The primary cilia arise from the basal body embedded in the cell membrane. Intraflagellar transport (IFT) carries requisite proteins from the cytoplasm to the cilium because the primary...
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Determination01:51

Determination

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During embryogenesis, cells become progressively committed to different fates through a two-step process: specification followed by determination. Specification is demonstrated by removing a segment of an early embryo, “neutrally” culturing the tissue in vitro—for example, in a petri dish with simple medium—and then observing the derivatives. If the cultured region gives rise to cell types that it would normally generate in the embryo, this means that it is specified. In...
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Neurulation01:30

Neurulation

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Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the...
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Mechanism of Ciliary Motion01:05

Mechanism of Ciliary Motion

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The ciliary structures were first seen in 1647 by Antonie Leeuwenhoek while observing the protozoans. In lower organisms, these appendages are responsible for cell movement, while in higher organisms, these appendages help in the movement of the extracellular fluids within the body cavities.
The cilia are made up of microtubules in a 9+2 arrangement, with nine microtubule doublet ring bundles, surrounding a pair of central singlet microtubule bundles. The doublet microtubule bundles are...
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Cell Polarization by Rho Proteins01:21

Cell Polarization by Rho Proteins

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Cell polarity is the asymmetric distribution of cellular and membrane components, making one side of the cell different from the other. This polarity is essential to many processes such as embryogenesis, axon migration, glucose transport across epithelial cells, and directional cell migration. A migrating cell responds to intracellular or extracellular signals via molecular cascades that reorganize the actin cytoskeleton to establish this polarity. In these cells, the Rho family proteins Cdc42,...
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Determining the Plane of Cell Division02:13

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Positioning the cell division plane is a critical step during development and cell differentiation, particularly during mitosis when the plane is essential for determining the size of the two daughter cells. The cell division plane is perpendicular to the plane of chromosome segregation, but different types of organisms have different cell division mechanisms to suit their morphology and function. 
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In animal cells, the cleavage furrow forms along the plane of cell division...
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相关实验视频

Updated: Jun 8, 2025

Using Primary Neurosphere Cultures to Study Primary Cilia
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Using Primary Neurosphere Cultures to Study Primary Cilia

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主要毛:编排头骨神经细胞的发育.

Hiroyuki Yamaguchi1, Matthew D Meyer2, William B Barrell3

  • 1Department of Pediatrics, McGovern Medical School at the University of Texas Health Science Center at Houston, Houston, TX, USA.

Differentiation; research in biological diversity
|November 5, 2024
PubMed
概括

主性乳毛作为细胞天线,调节细胞生长. 了解它们在头骨神经细胞中的功能,是解开头骨脸部纤毛病症的关键.

关键词:
西里亚 (Cilia) 是一个小体.产生是指产生的过程.头骨神经的细胞是神经顶细胞.头骨面部的发展信号传导传导是指信号的传导.

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2D and 3D Human Induced Pluripotent Stem Cell-Based Models to Dissect Primary Cilium Involvement during Neocortical Development
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2D and 3D Human Induced Pluripotent Stem Cell-Based Models to Dissect Primary Cilium Involvement during Neocortical Development

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Dissection, Culture and Analysis of Primary Cranial Neural Crest Cells from Mouse for the Study of Neural Crest Cell Delamination and Migration
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Dissection, Culture and Analysis of Primary Cranial Neural Crest Cells from Mouse for the Study of Neural Crest Cell Delamination and Migration

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相关实验视频

Last Updated: Jun 8, 2025

Using Primary Neurosphere Cultures to Study Primary Cilia
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2D and 3D Human Induced Pluripotent Stem Cell-Based Models to Dissect Primary Cilium Involvement during Neocortical Development
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Dissection, Culture and Analysis of Primary Cranial Neural Crest Cells from Mouse for the Study of Neural Crest Cell Delamination and Migration
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科学领域:

  • 细胞生物学 细胞生物学
  • 发展生物学 发展生物学
  • 遗传学 遗传学 是一个

背景情况:

  • 初级毛是基于微管的器官,对细胞信号传递至关重要.
  • 功能障碍的毛会导致面毛病,但机制尚不清楚.
  • 皮细胞调节细胞生长和分化.

研究的目的:

  • 讨论一次性乳毛在头骨神经细胞中的作用.
  • 探索头骨神经细胞中潜在的纤维生成机制.
  • 为了阐明面纤维病变的发病原因.

主要方法:

  • 文献综述和当前研究的综合.
  • 讨论初级毛的结构和功能.
  • 对纤毛发育途径的分析.

主要成果:

  • 主性毛在头骨神经细胞中充当信号中心.
  • 生成对于正常的面发育至关重要.
  • 毛的缺陷会影响细胞生长和分化.

结论:

  • 主要毛在头骨神经细胞功能中起着至关重要的作用.
  • 了解纤毛发育机制可以澄清面纤毛病的发病因子.
  • 需要进一步的研究才能充分理解在面发育中的作用.