免疫生物标志物,语音使用模式和声折损伤之间的关联:一个范围审查
Katharine Watson1, Jennifer Oates2, Catherine Sinclair3
1Department of Surgery, School of Clinical Sciences, Monash University, Melbourne, Victoria, Australia.
Journal of voice : official journal of the Voice Foundation
|November 5, 2024
概括
对于音声创伤声病变的免疫生物标志物的研究正在芽. 未来的研究应该专注于信号分子和系统性炎症的控制,以进一步了解语音使用影响.
科学领域:
- 免疫学 免疫学 免疫学
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 生物标志物 生物标志物
背景情况:
- 音创伤性声病变与炎症有关.
- 了解免疫生物标志物的作用对于诊断和治疗至关重要.
研究的目的:
- 探索免疫生物标志物和声损伤之间的潜在关联.
- 为未来的研究确定有前途的生物标志物.
主要方法:
- 对过去20年出版的文献进行综述.
- 搜索了包括Ovid MEDLINE,CINAHL,PubMed和Web of Science在内的数据库.
- 包括使用人类细胞系或生物样本进行客观免疫生物标志物测量的研究.
主要成果:
- 审查了4107篇论文,最终包括了28篇出版物.
- 确定了一个有限但不断增长的研究机构.
- 突出了采样和生物标志物检测敏感性的挑战.
结论:
- 对音声创伤声病变的免疫生物标志物的研究还处于早期阶段.
- 信号分子表现得有前途,作为语音使用相关病变的生物标志物.
- 未来的研究需要解决样本可访问性和全身炎症控制问题.
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