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在动物中对LivLonga®的毒理评估,LivLonga®是一种多草药组合

Anju Majeed1,2, Anjali Pandey1, Smitha Thazhathidath1

  • 1Research & Development, Sami-Sabinsa Group Limited, Bengaluru, Karnataka, India.

Drug and chemical toxicology
|November 5, 2024
PubMed
概括

在口服毒性研究中,LivLonga®是一种多草药配方,没有显示出毒性. 这种科学验证的混合物支持健康的肝功能,没有观察到600毫克/公斤/天的不良影响水平 (NOAEL).

关键词:
黄长提取物 黄长提取物加尔西尼亚印加的提取物没有观察到不良影响水平 (NOAEL)经合组织指导方针 经合组织指导方针毒性研究是毒性研究.

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Toxicity tests in animals are grounded on two main assumptions: first, the effects observed in laboratory animals can be extrapolated to humans, especially when adjusted for body surface area; second, high-dose exposure in animals is essential to identify potential human hazards from lower doses. This is based on the quantal dose-response concept, which faces the challenge of extrapolating results from relatively few test animals to much larger human populations. For example, a 0.01% incidence...