具有对LPS诱导的NO产生的抑制活性的小基素从Schisandra Chinensis中产生的NO
Ping Sun1, Xin-Cheng Zhuang1, Rui Ao1
1School of Biological Science and Technology, University of Jinan, Jinan, 250022, China.
Chemistry & biodiversity
|November 5, 2024
概括
从Schisandra chinensis的果实中分离出了七种新的线素,即schisanchignans A-G. 一些化合物表现出轻微的氧化抑制活性,首次报告了新的福和甲林类型.
科学领域:
- 自然产品化学 自然产品化学
- 植物化学 植物化学
- 有机化学 有机化学
背景情况:
- 中华是一种药用植物,以其多样化的植物化学成分而闻名.
- 类是S. chinensis中发现的一大类二次代谢物,表现出各种生物活动.
研究的目的:
- 为了对 Schisandra chinensis 果实进行植物化学调查.
- 为了分离和表征新的联化合物.
- 评估分离化合物的生物活性.
主要方法:
- 使用色谱技术分离化合物.
- 通过综合光谱分析 (NMR,MS) 阐明结构.
- 使用电子圆二元论 (ECD) 和量子化学计算来确定绝对配置.
主要成果:
- 隔离了七种新的小基,命名为schisanchignans A-G (1-7).
- 已分离的灵包括一种福类型 (1),三种甲类型 (2-4),以及三种四水类型 (5-7).
- 化合物1,3,和4在RAW264.7细胞中表现出对脂多糖糖诱导的氧化产生的轻度抑制活性.
结论:
- 这项研究报告了从Schisandra chinensis中首次分离出nor-benzofuran和aryltetralin类型的基.
- 这些已识别的化合物扩大了S. chinensis lignans.已知的化学多样性.
- 这些发现表明,某些S. chinensis lignans的潜在抗炎性质.
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