慢性大麻使用者的日常压力节奏的多模式检查
Nicholas C Glodosky1, Michael J Cleveland2, Reza Rahimi Azghan3
1Departments of Psychology, Washington State University, PO Box 644820, Pullman, WA, 99164-4820, USA.
Psychopharmacology
|November 5, 2024
概括
长期使用大麻会破坏日常皮质醇模式,但大麻可以缓解急性压力. 这项研究探讨了使用者的压力节奏和大麻影响.
科学领域:
- 神经内分泌学神经内分泌学
- 大麻研究 大麻研究
- 压力生理学 压力生理学
背景情况:
- 慢性大麻使用者通常将减轻压力作为主要动机.
- 内分泌系统调节神经内分泌应激反应.
- 慢性大麻使用者可能会改变白天皮质醇节律.
研究的目的:
- 调查大麻使用者中昼间压力节律的干扰.
- 研究大麻在自然环境中对压力标志物的急性影响.
主要方法:
- 唾液皮质醇和主观压力评级从82名参与者 (39名大麻使用者,43名非使用者) 处在每天8个时间点收集.
- 可穿戴设备监测了24小时的生理压力指标 (心率变化,皮电活动).
- 大麻使用者提供了使用前和使用后的样本,以评估急性大麻影响.
主要成果:
- 大麻使用者表现出皮质醇唤醒反应减弱,白天斜率平坦,下午皮质醇升高.
- 没有发现白天心率变化或皮电活动的显著差异,除了使用者晚上心率升高.
- 急性大麻使用导致皮质醇,主观压力和电皮活性显著降低.
结论:
- 有证据表明,大麻使用者的白天皮质醇节律失调,与晚起时间有关.
- 大麻使用在自然环境中表现出急性减压特性.
- 需要进一步的研究来澄清大麻使用与皮质醇节奏以及对心理健康的影响之间的双向关系.
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