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与胎儿生长限制相关的缺血症:一个多中心描述性和预后性队列研究

Manon Marquet¹, Olivia Anselem¹, Claire Bouvattier²

¹Department of Obstetrics and Gynecology, AP-HP, Port-Royal Maternity, Université Paris Cité, Paris, France.

Prenatal diagnosis

|November 5, 2024

概括

胎儿生长限制 (FGR) 和hypospadias的组合,即使单独出现,也与遗传或内分泌问题有关. 低血压症的手术结果可能很复杂,往往需要重新干预.

科学领域:

医学遗传学医学遗传学
产前诊断在产前诊断
儿科手术儿科手术

背景情况:

缺血症和胎儿生长限制 (FGR) 是重要的先天性疾病.
在FGR和hypospadias的同时发生,需要进一步调查潜在的异常和结果.

研究的目的:

确定患有FGR和hypospadias的胎儿中遗传和内分泌异常的患病率.
在这个特定的患者队列中评估胎儿,新生儿和手术结果.

主要方法:

一项多中心的回顾性研究,涉及82名被诊断患有FGR (<10百分位) 和hypospadias的胎儿.
收集的数据包括母亲,胎儿,产前和产后信息,以及遗传和内分泌学评估.

主要成果:

17%的病例涉及终止怀孕,5%的病例在子宫内死亡.
在单独出现的病例中,12%显示染色体,遗传或内分泌异常.
50%的hypospadias是近端的,而50%的手术干预导致了需要重新手术的并发症.

结论:

由于潜在的潜在遗传/内分泌问题,应该仔细评估FGR和低血压的关联,即使在看似孤立的病例中也是如此.
在这种情况下,对低血压症的手术管理可能具有挑战性,并发症和重新干预的比例很高.

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