基托桑基纳米配方:临床前研究,治疗前期进展和临床试验前景,用于针对各种病理
Seema Yadav1, Abhishek Singh1, Narahari N Palei2
1Amity Institute of Pharmacy, Amity University, Lucknow, Sector 125, Noida, Uttar Pradesh, 201313, India.
AAPS PharmSciTech
|November 5, 2024
概括
基托桑纳米载体提供了多功能药物输送解决方案. 这次审查涵盖了它们对各种疾病的临床前和临床应用,包括监管批准的挑战.
科学领域:
- 生物材料科学 生物材料科学
- 纳米技术纳米技术
- 药物输送系统 药物输送系统
背景情况:
- 奇托是一种生物相容,生物降解的聚合物,具有可调节的特性.
- 基托桑纳米颗粒具有正面电荷和粘膜粘合,可增强药物输送.
- 这些特性使得治疗剂的向输送和受控释放成为可能.
研究的目的:
- 在各种治疗应用中全面审查基托基纳米载体.
- 探索他们的旅程从临床前研究到临床试验和theranostics.
- 识别和解决在临床翻译的基托纳米配方监管挑战.
主要方法:
- 关于基托纳米配方的临床前研究的文献综述.
- 在各种疾病模型中分析异能学应用.
- 对基托基纳米药物的临床试验数据和监管障碍的审查.
主要成果:
- 素纳米配方在优化药物输送和改善治疗结果方面显示出显著的潜力.
- 应用范围包括神经,心血管,癌症,伤口愈合,胃肠道和肺部疾病.
- 重点介绍了临床翻译中的治疗能力和进步.
结论:
- 基托桑纳米载体对先进的药物输送和神经科学有前途.
- 为了成功的临床实施,需要进一步的研究和监管策略.
- 本综述提供了关于基托基纳米药物的广泛潜力和挑战的见解.
更多相关视频
05:55Synthesis and Characterization of Placental Chondroitin Sulfate A plCSA-Targeting Lipid-Polymer Nanoparticles
Published on: September 18, 2018
8.7K
14:20Polymalic Acid-based Nano Biopolymers for Targeting of Multiple Tumor Markers: An Opportunity for Personalized Medicine?
Published on: June 13, 2014
16.7K
相关概念视频
Targeted Cancer Therapies
7.5K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.5K
Preclinical Development: Overview
4.2K
Preclinical development consists of a series of tests that ensure the safety and efficacy of a new therapeutic compound before it is tested in humans. There are four main phases to this process. First, safety pharmacology tests are conducted to ensure the drug does not produce any acutely harmful effects. These tests examine parameters such as bronchoconstriction, cardiac dysrhythmias, blood pressure changes, and ataxia. Next, preliminary toxicological testing is performed to determine the...
4.2K
Microorganisms in Medicine and Therapeutics
1
Microorganisms play a fundamental role in vaccine development, gene therapy, and therapeutic production. Their biological properties are harnessed to advance medicine and public health. Beyond immunization, microorganisms contribute to gut health, antibiotic synthesis, and genetic disease treatment.Live Attenuated and Inactivated VaccinesLive attenuated vaccines, such as the measles, mumps, and rubella (MMR) vaccine, utilize weakened forms of pathogens to closely resemble natural infections.
1
