从轻度到中度的COVID-19中恢复过来的个体中的肺扩散能力:一个横截面研究
Dana Yelin1,2, Nassem Ghantous3, Muhammad Awwad3
1Infectious Diseases Unit, Sheba Medical Center, Ramat Gan, Israel. dana.yelin@gmail.com.
Scientific reports
|November 5, 2024
概括
对一氧化碳 (DLCO) 的扩散能力降低在轻度疾病后的长期COVID患者中很常见. 女性和吸烟者面临更高的风险,呼吸障碍的严重程度与肺功能受损相关.
科学领域:
- 肺部病理学 肺部病理学
- 传染性疾病 传染性疾病
- 长时间的COVID研究
背景情况:
- 对一氧化碳的肺扩散能力受损 (DLCO) 是已知的严重COVID-19后的并发症.
- 长期COVID经常跟随轻度至中度的急性疾病,其中DLCO变化不太了解.
研究的目的:
- 在轻度至中度急性疾病后,评估长期COVID患者的DLCO.
- 为了确定与该人群中DLCO受损相关的临床因素.
主要方法:
- 对458名长期COVID症状>3个月后的成年人进行横截面研究.
- 肺功能测试 (PFT),包括DLCO测量.
- 多变量逻辑回归用于识别受损DLCO的相关物 (预测<80%).
主要成果:
- 在17%的队列中观察到较低的DLCO.
- 损伤的DLCO与女性性别 (OR 3.64),吸烟 (OR 2.25) 和中度至重度呼吸障碍 (OR 2.77) 有关.
- 较高的BMI与DLCO (或每单位0.90) 反对相关.
结论:
- 损坏的DLCO在从轻度至中度疾病中恢复的长期COVID患者中普遍存在.
- 女性性别,吸烟和主观呼吸障碍是减少DLCO的关键相关因子.
- 自我报告的呼吸障碍可以指导肺功能障碍的临床评估.
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