在2型糖尿病患者中,血液中的重金属与糖尿病病之间的关联:一个横截面研究
Hongling Zhao1,2, Ruili Yin1,2, Yan Wang1,2
1Center for Endocrine Metabolism and Immune Diseases, Beijing Luhe Hospital Capital Medical University, Beijing, China.
Scientific reports
|November 5, 2024
概括
暴露于重金属,特别是 (Pb),与2型糖尿病患者糖尿病病 (DKD) 风险增加有关. 混合金属暴露也会增加DKD的风险,特别是在特定的人口群体中.
科学领域:
- 环境健康 环境健康
- 腎臟病學 (nephrology) 是一種醫學.
- 内分泌学 在内分泌学.
背景情况:
- 糖尿病病 (DKD) 是2型糖尿病 (T2DM) 的一个主要并发症.
- 关于重金属暴露和DKD之间的相关性存在有限的研究,特别是关于混合金属冲击的研究.
- 了解环境风险因素对于预防和管理DKD至关重要.
研究的目的:
- 研究血液中重金属含量与T2DM患者的DKD风险之间的关联.
- 评估单金属和混合金属暴露对DKD发展的影响.
- 为了确定特定的人口分组在更高的风险.
主要方法:
- 使用NHANES数据 (2011-2020年) 的横截面研究,涉及2362名T2DM参与者.
- 诱导合血质谱法 (ICP-MS) 用于测量血液中 (Pb), (Cd), (Hg), (Se) 和 (Mn) 的含量.
- 采用了多变量逻辑回归,加权量子总和 (WQS) 回归和贝叶斯核心机器回归 (BKMR) 模型.
主要成果:
- 经过对共变量进行调整后,血中 (Pb) 含量升高与DKD风险增加显著相关 (OR [95% CI]: 1.557 [1.175, 2.064]).
- WQS和BKMR分析证实Pb暴露与较高的DKD发病率之间存在正相关性.
- 暴露在重金属混合物中也与增加DKD风险有显著联系.
- 亚组分析显示,Pb与女性,50岁以上的个体,BMI>25 kg/m2,没有高血压,非吸烟者和较低PIR的DKD有显著的关联.
结论:
- 混合金属度增加可能会增加T2DM患者的DKD风险.
- 血 (Pb) 与DKD风险有积极的关联,特别是在易受伤害的子组中.
- 暴露于似乎影响了DKD的发生和进展,这需要进一步的机制研究.
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