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Paul Stammer¹, Inka Terhorst¹, Jiangang Guo^1,2

¹Clinic for Vascular and Endovascular Surgery, University Hospital Münster, Albert-Schweitzer-Campus 1, 48149, Münster, Germany.

Scientific reports

|November 5, 2024

概括

溶性VE-cadherin (sVEC) 脱落与血管疾病中的TNF-α和ADAM10/17有关. 虽然sVEC水平在大动脉疾病和其他疾病中没有显著差异,但它们的相关性突显了大动脉病理生理学中的作用.

科学领域:

心血管生物学心血管生物学
内皮细胞生物学内皮细胞生物学
保护酶的功能保护酶的功能

背景情况:

VE-cadherin (VEC) 对于血管平衡至关重要.
在血管疾病期间,蛋白酶ADAM10/17在对TNF-α的反应中释放VEC.
可溶性VEC (sVEC) 碎片是内皮屏障分解的潜在标志物.

研究的目的:

研究sVEC产生与ADAM10/17和TNF-α的特异性和联系.
确定sVEC作为大动脉疾病的特定生物标志物的作用.
在患有大动脉动脉瘤/解剖症的患者中比较sVEC水平与大动脉狭窄/静脉缩.

主要方法:

在患者中测量了sVEC,TNF-α,ADAM10和专蛋白的血水平.
使用了用TNF-α或蛋白酶抑制剂治疗的人类大动脉内皮细胞 (HAEC).
通过使用德克斯进行透性测试,评估HAEC单层完整性.

主要成果:

在体外,TNF-α诱导了依赖于ADAM10/17的VEC脱落,改变了内皮透气性.
血sVEC水平在患有大动脉剖析,动脉瘤,大脑管狭窄和静脉的患者中是相似的.
血sVEC水平与TNF-α和ADAM10正相关,特别是在慢性大动脉剖析中.

结论:

维埃克的分泌和sVEC的血水平受到TNF-α和ADAM10/17的影响.
这些因素可能在大动脉疾病的病理生理学中发挥重要作用.
作为大动脉疾病的特定生物标志物,sVEC的实用性需要进一步研究.

关键词:

亚当10 亚当10 亚当大动脉疾病是大动脉疾病.微生物群中的微生物群这就是TNF-α.这就是VE-cadherin.

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