在患有正常冠状动脉的患者中,糖尿病前期和糖尿病中内皮功能障碍
Asli Inci Atar1, Tugba Kayhan Altuner2, Huseyin Bozbas3
1Ankara Bilkent City Hospital, Bilkent, Ankara, 06800, Turkey. asliatar@gmail.com.
BMC cardiovascular disorders
|November 5, 2024
概括
糖尿病患者表现出显著的内皮功能障碍,与糖尿病前期患者不同. 糖尿病前期的早期干预可以预防先进的内皮功能障碍和心血管疾病风险.
科学领域:
- 心血管研究研究心血管研究
- 代谢障碍 代谢障碍 代谢障碍
- 血管生物学 血管生物学
背景情况:
- 糖尿病 (DM) 增加了心血管疾病 (CVD) 的风险,内皮功能障碍是关键因素.
- 内皮功能障碍在动脉样硬化和心血管疾病之前,在DM并发症中起作用.
- 关于使用流媒扩张 (FMD) 的糖尿病前期患者内皮功能存在有限的数据,特别是排除了患有动脉样硬化症的患者.
研究的目的:
- 通过手臂动脉流介导扩张 (FMD) 来评估内皮功能.
- 为了比较患有糖尿病 (DM),糖尿病前期和正常血糖控制的患者的口病与正常冠状动脉.
主要方法:
- 包括73名参与者:25名患有糖尿病,25名患有糖尿病前期,23名对照,所有人的冠状动脉正常.
- 进行了手臂动脉的标准化口炎测量.
- 统计分析比较了三个组的口和口腔疾病水平.
主要成果:
- 群体在人口统计学上相似,除了禁食血葡萄糖.
- 与糖尿病前期患者 (16.5%) 和对照患者 (14.8%) (P=0.004) 相比,DM患者 (10.1%) 的口腔炎水平显著降低 (P=0.004).
- 在糖尿病前期和对照组之间没有观察到明显的口病差异.
结论:
- 与正常血糖患者相比,糖尿病患者表现出显著的内皮功能障碍.
- 在这项研究中,糖尿病前患者没有表现出显著的内皮功能障碍.
- 研究结果表明,糖尿病前期为预防进一步的内皮功能障碍提供了一个关键的干预窗口.
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