相关实验视频
Updated: May 7, 2026
08:20
A Hyperandrogenic Mouse Model to Study Polycystic Ovary Syndrome
Published on: October 2, 2018
11.2K
孕激素峰值在触发日影响胚胎发育形态动力学? 一个回顾性研究研究
D Baldini1, V M Bartoli2, A Mastrorocco2
1MOMO' FertiLIFE, IVF Clinic, Bisceglie, 76011, Italy. dbaldini@libero.it.
Journal of ovarian research
|November 6, 2024
概括
在hCG触发日早产激素升高 (PPR) 超过1.5ng/ml,在ICSI周期中不会损害胚胎发育. 相反,它与更快的初始胚胎发育和更高档的胚胎细胞相关.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 辅助生殖技术 辅助生殖技术
- 胚胎学 胚胎学
背景情况:
- 早发性孕激素升高 (PPR) 被定义为接近hCG触发的血清孕激素水平升高.
- 关于PPR对细胞内精子注射 (ICSI) 结果的影响仍然是调查的主题.
研究的目的:
- 评估孕激素水平≥1.5ng/ml在hCG触发日对胚胎形态动力学的影响.
- 在PPR的背景下,确定ICSI周期成功的潜在预测生物标志物.
主要方法:
- 对116个ICSI周期 (2020-2023) 的回顾性研究,将58名孕激素≥1.5ng/ml的患者 (研究组) 与58名孕激素<1.5ng/ml的对照患者进行比较.
- 收集了患者的基线特征 (年龄,BMI,AFC,AMH,FSH) 和ICSI周期数据 (取回的卵子,受精的卵子,胚芽细胞).
- 利用时间缩短技术评估胚胎形态动力学和胚胎细胞质量.
主要成果:
- 孕激素水平升高 (≥1.5 ng/ml) 与较高的腹膜毛囊数量有关,导致更多的取回卵子,成熟卵子,受精卵子和胚芽细胞.
- 形态动力学分析显示,研究小组的初始胚胎分裂时间更快.
- 在孕激素升高的患者中,观察到显著更多的高等级芽细胞瘤.
结论:
- 在hCG触发日的孕水平≥1.5ng/ml在ICSI周期中不会对胚胎形态动力学参数产生负面影响.
- 孕激素升高可能与更快的早期胚胎发育有关.
- 较高的孕激素水平可能与改善的胚胎细胞质量和数量相关.
更多相关视频
相关概念视频
01:07Teratogenicity
The ability of a drug to produce structural deformations and functional abnormalities in the developing embryo or the fetus is called teratogenicity, and the drug producing this effect is known as a teratogen. Teratogenic effects include stillbirth, miscarriage, intrauterine growth restriction, and neurocognitive delay. A teratogen may affect the embryo at different stages of development, which is important in determining the type and extent of the damage. During blastocyst formation, the early...
01:22Hormonal Regulation of the Menstrual Cycle
The ovarian cycle regulates endometrial changes throughout a single menstrual cycle via the coordinated action of gonadotrophin-releasing hormone (GnRH) and gonadotrophins.
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH release.
At puberty, GnRH begins a pulsatile release pattern, which triggers the anterior pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). The frequency and amplitude of GnRH pulses vary across the menstrual cycle, with faster pulses favoring LH release and slower pulses favoring FSH release.
01:27Ovarian Cycle
The menstrual cycle includes a critical component known as the ovarian cycle, which undergoes two main phases each month—the follicular phase and the luteal phase. The follicular phase is variable and averaging around 14 days. Ovulation, triggered by a surge in luteinizing hormone (LH), marks the transition between the two phases. The second phase, the luteal phase, is relatively consistent, lasting approximately 14 days, and is marked by the activity of the corpus luteum. While a cycle length...
01:20Proliferative Phase
The proliferative phase typically occurs after menstruation and lasts between 6 to 13 days in a standard 28-day cycle. This phase involves the reconstruction of the endometrium, guided by estrogen produced by the developing ovarian follicle.
Notably, the stratum basale, the basal layer of the endometrium, including the basal parts of the uterine glands, remains unaffected by menstruation. Stem cells in this layer undergo mitosis, regenerating the stratum functionalis and thickening the...
Notably, the stratum basale, the basal layer of the endometrium, including the basal parts of the uterine glands, remains unaffected by menstruation. Stem cells in this layer undergo mitosis, regenerating the stratum functionalis and thickening the...