一项全国性的瑞典对2000年至2022年间中毒死亡的回顾性研究
Elin Lindqvist1,2, Jacob Hollenberg1,3, Mattias Ringh1,3
1Department of Clinical Science and Education SÖS, Center for Resuscitation Science, Karolinska Institute, Stockholm, Sweden.
Basic & clinical pharmacology & toxicology
|November 6, 2024
概括
在瑞典,中毒死亡人数占1.3%,主要影响50多岁的男性. 合成麻醉品,阿片类药物和酒精是主要原因,这些中毒死亡的尸检率低于预期.
科学领域:
- 法医毒理学 法医毒理学
- 公共卫生监督 公共卫生监督
- 死亡率研究 死亡率研究
背景情况:
- 在瑞典,中毒是死亡的一个重要原因,每年约占死亡人数的1%.
- 了解中毒致死者的人口统计和毒理学对于公共卫生干预至关重要.
研究的目的:
- 描述瑞典受致命中毒影响的人口.
- 分析这些病例中尸检频率和毒理学测试结果.
- 确定导致中毒死亡的主要物质.
主要方法:
- 一项利用2000-2021年瑞典国家登记册进行的国家队列研究.
- 包括所有18岁以上死亡的个人,注册死亡原因是中毒.
- 分析主要的ICD-10代码和法医化学测试结果.
主要成果:
- 发生了超过27,000例中毒死亡,平均年龄为53岁;70%是男性.
- 合成麻醉品,阿片类药物和酒精是主要原因,分别造成46%和33%的死亡.
- 乙醇,佐皮克隆和诺达泽是毒理学测试中最常检测到的物质.
结论:
- 致命中毒占瑞典死亡率的1.3%,主要影响中年男性.
- 合成麻醉品,阿片类药物和酒精是这些死亡的主要驱动因素.
- 观察到中毒死亡的尸检频率明显低于预期.
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