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催化活性Ti基纳米材料用于基基基媒介临床X射线增强

Lukas R H Gerken^1,2, Claire Beckers³, Beatrice A Brugger²

¹Nanoparticle Systems Engineering Laboratory, Institute of Energy and Process Engineering (IEPE), Department of Mechanical and Process Engineering (D-MAVT), ETH Zurich, Sonneggstrasse 3, Zurich, 8092, Switzerland.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

|November 6, 2024

概括

基于的纳米材料,包括MOFs和MXenes,显示了增强放射治疗的前景. 这些材料有效地增加了各种X射线能量的瘤细胞的辐射损伤,为癌症治疗提供了选择性的方法.

科学领域:

生物医学工程生物医学工程
材料科学材料科学材料科学
放射治疗研究放射治疗研究

背景情况:

纳米粒子辐射增强旨在通过增加瘤中的局部辐射损伤来改善放射治疗.
高原子数纳米材料 (例如,Au,HfO2) 与临床大电压X射线相比,与研究正电压X射线相比,其效率较低.
需要纳米材料来维持放射增强的有效性,在临床环境中具有相关性的广泛X射线能量频谱.

研究的目的:

设计和研究用于临床X射线治疗的放射催化活性基纳米材料.
评估各种基于的材料的放射增强性能,包括TiO2,金属有机框架 (MOF) 和MXenes,在不同的X射线能量范围内.
了解放射增强的机制,专注于超越物理剂量增强的反应性氧物种生成.

主要方法:

基于的纳米材料 (TiO2,Ti-MOFs,Ti3C2Tx MXenes) 的合成和表征.
使用正电压和巨电压X射线源对放射增强疗效的评估.
在人类软组织肉瘤和健康纤维细胞细胞中评估反应性氧气物种的产生和细胞吸收.
在生物模型中量化剂量增加因子.

主要成果:

基于的纳米材料在正极电压和大极电压X射线能量中表现出一致的辐射增强性能.
观察到的增强归因于反应性氧物种的催化生成,这种机制与光电效应不同.
基于的MOF和MXenes在人类软组织肉瘤细胞中实现了高达3的剂量增强因子.
观察到选择性增强,对健康的人类纤维细胞细胞的影响最小,表明有针对性的治疗潜力.

结论:

具有放射性催化活性的基于的纳米材料在临床X射线治疗环境中对放射增强有效.
由于这些材料的作用机制,它们在传统的高原子数纳米粒子上提供了持续的性能优势.
基于的MOF和MXenes是开发新型选择性放射治疗策略的有希望的候选者,可以改善瘤向和减少副作用.

关键词:

光催化剂是一种光催化剂.辐射敏感化辐射敏感化辐射疗法辐射疗法有活性氧物种的反应性氧物种.的是什么的是什么

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