客观测量的久坐行为与动脉硬的关联:尼姆根运动研究的发现
Koen M van der Sluijs1, Esmée A Bakker1,2, Thijs P Kerstens1
1Department of Medical BioSiences, Radboud University Medical Center, Nijmegen, The Netherlands.
Scandinavian journal of medicine & science in sports
|November 6, 2024
概括
久坐不动的行为 (SB) 并没有影响成年人中枢动脉硬. 然而,增加的SB与患有较高静脉血压或中度至强度体力活动 (MVPA) 水平的个体中较大的局部动脉硬性有关.
科学领域:
- 心血管生理学心血管生理学
- 公共卫生 公共卫生
- 运动科学 运动科学
背景情况:
- 久坐不动行为 (SB) 是与心血管疾病相关的日益严重的公共卫生问题.
- 动脉硬是心血管疾病风险的早期指标.
- 客观测量的SB与动脉硬之间的关系需要进一步研究.
研究的目的:
- 检查客观测量的SB与中央和局部动脉硬度之间的关联.
- 确定修改SB和动脉硬之间的关系的因素.
主要方法:
- 使用加速度计在八天内对 SB 的客观测量.
- 通过动脉-大腿脉冲波速度 (cfPWV) 评估中枢动脉硬度.
- 使用超声波测量局部动脉硬度 (硬度指数Beta和压力应变弹性EP).
- 使用线性回归进行统计分析,对混因素进行调整,并对效果修改进行交互术语.
主要成果:
- 在SB和中央动脉硬 (cfPWV) 之间没有发现显著的关联.
- 在患有较高静脉血压 (静脉血压>134 mmHg) 的参与者中,SB与局部心动脉硬性 (Beta和E) 有积极关联.
- 在具有较高中度至强度体力活动 (MVPA) 量 (>103分钟/天) 的参与者中,SB也与局部心血管硬有关.
结论:
- 客观测量SB与中枢动脉硬性无关.
- 在特定的亚组中,SB与局部冠状动脉硬度增加有关,即那些SBP或MVPA较高的亚组.
- 这些发现表明,SB可能会导致某些人群的动脉硬化,加强其与心血管疾病风险的联系.
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