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工程应变缺陷以增强酶疗法和诱导铁亡

Sida Cao¹, Shuming Dong¹, Lili Feng¹

¹Key Laboratory of Superlight Materials and Surface Technology, Ministry of Education, College of Materials Science and Chemical Engineering, Harbin Engineering University, Harbin, 150001, P. R. China.

Advanced materials (Deerfield Beach, Fla.)

|November 6, 2024

概括

这项研究引入了一种多功能纳米酶,MMSR-pS-PEG,通过结合酶模仿和铁死来增强瘤治疗. 这种纳米酶有效地产生反应性氧物种,并诱导癌细胞死亡,以改善治疗结果.

科学领域:

生物材料科学生物材料科学
纳米技术纳米技术
癌症治疗癌症治疗

背景情况:

酶模拟催化通常由于活性不足而表现出有限的有效性.
单一的治疗策略不足以满足全面的癌症治疗需求.

研究的目的:

设计和制造一个多功能纳米酶,MMSR-pS-PEG,用于增强癌症治疗.
在瘤微环境中研究酶模拟和ferroptosis诱导的协同效应.

主要方法:

用pS-PEG修饰和装载索拉芬尼 (SRF) 的中孔空洞MnMoO_x球体的制造.
利用应变工程来诱导氧气缺陷以增强双酶活性 (催化酶和氧化酶).
利用MnMoO_x的n型半导体特性,在超声波照射下产生活性氧物种和减少谷氨.

主要成果:

该纳米酶显示出增强的双酶活性,在酸性瘤微环境中将H₂O₂转化为氧和超氧化物离子.
对MnMoO_x的超声波照射产生了活性氧物种和耗尽的谷氨,放大了催化效应.
索拉非尼 (SRF) 作为铁灭症诱导剂,与纳米酶协同作用,促进脂质过氧化和抑制谷氨合成,最终刺激铁灭症.

结论:

开发的多功能纳米酶MMSR-pS-PEG在酶性瘤治疗中表现出高性能.
这种方法提供了一个有希望的策略,用于结合铁和酶疗法,以获得协同作用的抗癌效应.

关键词:

酶疗法是一种酶疗法.酶性活动酶性活动铁性化 (ferroptosis) 是一种索拉芬尼布 (Sorafenib) 是一个应变缺陷工程的工程.

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