用边缘激活剂 (Tween20) 制备的Soluplus稳定型尼莫迪平因捕获的塑配方:比较物理化学评估
Hussein K Alkufi1, Hanan J Kassab2
1Department of Pharmacognosy, College of Pharmacy, University of Thi-Qar, 64001, Iraq.
Pharmaceutical nanotechnology
|November 6, 2024
概括
这项研究使用乙醇注射方法成功将尼莫迪平 (ND) 配制成塑性纳米微粒,显著提高了其用于治疗下关节出血的生物可用性. 优化的配方表现出增强的稳定性和药物释放特性.
科学领域:
- 纳米技术纳米技术
- 制药科学 制药科学
- 药物输送系统 药物输送系统
背景情况:
- 尼莫迪平 (ND) 是急性脑下关节出血的一个关键血管扩张剂.
- 它的疏水性质导致溶解性差,生物可用性低.
- 斯潘拉斯基纳米微粒为增强药物输送提供了一个潜在的解决方案.
研究的目的:
- 为了将尼莫迪平 (ND) 配制成塑料纳米纤维.
- 为了提高尼莫迪平的生物可用性.
- 评估纳米管状配方的物理化学特性和体外性能.
主要方法:
- 使用乙醇注射方法制备含有ND的Spanlastic纳米丝片.
- 配方使用Span60 (非离子表面活性剂) 和Tween 20 (边缘激活剂).
- 结合了像Soluplus这样的稳定剂,并与非稳定配方进行了比较;特征包括囊泡大小,PDI,%EE,zeta潜力和体外释放.
主要成果:
- 优化的配方 (F27) 呈现出有利的特征:囊泡大小 (VS) 为 125.7±0.29 nm,多分散指数 (PDI) 为 0.4744±0.002,捕获效率 (%EE) 为 85.43±0.17%,泽塔电位为 -20.01 ± 0.89 mV.
- 含有Soluplus的配方显示出更好的稳定性和更高的可变性指数 (DI).
- 扫描电子显微镜 (SEM) 揭示了均和球形的纳米,表明持续释放能力.
结论:
- 乙醇注射方法是有效的,以制订ND到spanlastic纳米丝片.
- 索鲁普卢斯作为稳定剂,防止晶体的发育和聚合,导致更稳定的配方.
- 开发的spanlastic nanovesicles显示了通过提高其生物可用性来改善尼莫迪平的治疗疗效的前景.
相关概念视频
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