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Updated: Jun 8, 2025

A11-positive β-amyloid Oligomer Preparation and Assessment Using Dot Blotting Analysis
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多孔有机作为Aβ聚合的抑制剂:一个模拟研究

Daohui Zhao1, Yu Zhou1, Fen Xing2

  • 1Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials, Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules, School of Chemistry and Chemical Engineering, Hubei University, Wuhan 430062, P. R. China. wanghx@hubu.edu.cn.

Physical chemistry chemical physics : PCCP
|November 6, 2024
PubMed
概括

多孔有机 (POC),特别是CC3晶体,通过防止粉样β 42 (Aβ42) 聚合,显示出抑制阿尔茨海默病 (AD) 的前景. 分子动力学模拟显示CC3晶体改变了Aβ42结构,降低了毒性.

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Amyloid fibrils are aggregates of misfolded proteins.  Under most circumstances, misfolded proteins are either refolded by chaperone proteins or degraded by the proteasome. However, in the case of a mutation or a disease, these proteins can accumulate to form large clusters and often further assemble to form elongated fibers, called fibrils. 
Amyloid deposits were observed as early as 1639 in the liver and the spleen.   In 1854, Rudolph Virchow performed iodine staining,...
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