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Updated: Jun 8, 2025

Generation of 3D Skin Organoid from Cord Blood-derived Induced Pluripotent Stem Cells
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推进皮肤模型开发:专注于自组装,诱导多能干细胞衍生,无外基因的方法

Marla Dubau1, Tarada Tripetchr1, Lava Mahmoud1

  • 1Department of Pharmacology and Toxicology, Institute for Pharmacy, Freie Universität Berlin, Berlin, Germany.

Journal of tissue engineering
|November 6, 2024
PubMed
概括

研究人员使用诱导多能干细胞 (iPSC) 开发了自组装皮肤模型 (SASM),作为动物试验的无外基因替代品. 这些伦理模型为皮肤学研究和监管决策提供可靠的物质评估.

关键词:
发毛囊衍生细胞的细胞.纤维细胞的细胞.诱导多能干细胞的诱导干细胞.角质细胞 (keratinocytes) 是一种细胞.重编程是重新编程.自组装的皮肤模型没有异的方法.

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Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
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