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内皮衍生微粒与医院主要不良心血管事件相关,但与急性心肌梗塞的长期不良事件无关

Anggoro B Hartopo¹, Dyah S Mayasari^1,2, Ira Puspitawati³

¹Department of Cardiology and Vascular Medicine, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada-Dr. Sardjito Hospital, Yogyakarta, Indonesia.

The International journal of angiology : official publication of the International College of Angiology, Inc

|November 6, 2024

概括

在急性心肌梗塞 (AMI) 患者中,更高的入院内皮质衍生微粒 (EDMP) 预测了医院内主要不良心血管事件 (MACE). 然而,EDMP水平和释放后的变化不会影响MACE的长期结果.

科学领域:

心血管医学心血管医学
生物标志物生物标志物
血管生物学血管生物学

背景情况:

内皮衍生微粒 (EDMP) 是血管健康的关键指标.
EDMP在凝血,炎症和亡中起作用,与急性心肌梗塞 (AMI) 有关.

研究的目的:

为了确定入院时的EDMP水平是否会对AMI患者的住院重大心血管不良事件 (MACE) 有影响.
评估EDMP水平的变化是否会在退院30天后影响长期的MACE.

主要方法:

119名连续AMI患者的前性队列研究.
在入院和出院30天后测量EDMP.
评估了住院MACE (心脏死亡率,心力衰竭,休克,心脏复发,心律失常) 和长期随访 (30天,90天,1年).

主要成果:

在住院MACE患者 (27,421.0对11,617.5计数/μL,p=0.028) 中,入院时的EDMP计数显著更高.
>26,810.0 EDMP/μL的切线预测了医院MACE的增加 (aOR:4.45,p=0.008).
排放后30天,EDMP数量显著增加,但无论是入院还是排放EDMP水平,或者它们的变化,都没有预测长期MACE.

结论:

升高的入院EDMP水平与AMI患者的住院MACE独立相关.
入院时和出院后30天的EDMP水平及其变化不能预测AMI后的长期MACE结果.

关键词:

心血管疾病心血管疾病细胞衍生微粒来自细胞的微粒.心肌梗塞的心脏病发作预后预后预后

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