阴道神经刺激参数对患者心率变化的影响
Ahmet Genç1, Firdevs Ezgi Uçan Tokuç2, Meltem Korucuk2
1Department of Cardiology, Antalya Provincial Health Directorate, Antalya Training and Research Hospital, Antalya, Türkiye.
Frontiers in neurology
|November 6, 2024
概括
对于而言的阴道神经刺激 (VNS) 以复杂的方式影响心率变化 (HRV). 特定的VNS参数影响HRV,HRV可以预测VNS治疗反应.
科学领域:
- 神经学 神经学
- 心脏病学 心脏病学
- 生物医学工程 生物医学工程
背景情况:
- 阴道神经刺激 (VNS) 是药物耐药性的已知治疗方法.
- VNS对心脏自主系统的影响仍然是争论的主题.
- 了解VNS对心率变化 (HRV) 的影响对于优化治疗至关重要.
研究的目的:
- 研究患者的VNS参数和HRV之间的关系.
- 为了确定潜在的HRV生物标志物来预测VNS治疗疗效.
主要方法:
- 研究了一组31名接受VNS治疗的患者.
- 所有参与者都进行了24小时的霍尔特心电图监测.
- 根据治疗结果,患者被分为VNS响应群和非响应群.
主要成果:
- 与非响应者相比,VNS响应者在HRV中表现出明显较低的高频 (HF) 功率.
- VNS持续时间和信号频率与LF/HF比率正相关.
- VNS输出和休息时间对LF/HF比率产生了负面影响.
- 接收器操作特征 (ROC) 分析表明HF的曲线下面面积 (AUC) 为0.780,预测VNS响应的截止值为156.9.
结论:
- VNS通过与HRV参数的复杂相互作用影响自主神经系统.
- 特定的VNS参数设置调节HRV,有助于其复杂的影响.
- HRV参数作为预测生物标志物,有望用于识别可能受益于VNS治疗的患者.
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