设计和合成一种新型的异黄素衍生的希夫基联体:结构特征,分子对接和体外生物活性评估
Wassila Derafa1, Bassant S Moustafa2, Gehad G Mohamed3
1Department of Chemistry, College of Science, Jouf University, Aljouf, Saudi Arabia.
International journal of health sciences
|November 6, 2024
概括
新的希夫基础金属复合物显示出显著的抗菌,抗真菌和抗繁殖活性. 这些化合物显示出作为治疗感染和乳腺癌的潜在治疗剂的前景.
科学领域:
- 协调化学 协调化学
- 药用化学 医学化学
- 材料科学 材料科学 材料科学
背景情况:
- 希夫基是具有多种应用的多功能化合物,包括催化,稳定和合成构建块.
- 它们具有广泛的生物活性,如抗真菌,抗菌,抗病毒,抗增殖,抗炎和抗发烧作用.
研究的目的:
- 合成一种新型的希夫基联结体 (HL) 来自异酸,2,6-二胺胺和异氨酸.
- 准备和描述合成的连接体的过渡金属复合体.
- 评估配体及其金属复合物的抗微生物,抗增殖和结构性质.
主要方法:
- 通过凝结反应合成联结体.
- 复杂的形成与各种过渡金属离子 (Cr, Fe, Mn, Cu, Cd, Co, Zn, Ni).
- 使用元素分析,IR,1H-NMR,UV-vis,质谱,热分析,X射线衍射和扫描电子显微镜进行表征.
- 抗微生物和抗增殖活性测定.
- 分子对接研究. 分子对接研究.
主要成果:
- 连接体 (HL) 和其金属复合物已成功合成和表征.
- 综合体表现出不同的几何形状 (四面体和八面体) 和电解行为.
- 与自由连接体相比,金属复合体对MCF-7乳腺癌细胞具有增强的抗菌,抗真菌和抗增殖活性.
- 分子对接表明了针对特定生物点的抑制潜力.
结论:
- 合成的希夫基础金属复合物具有作为治疗微生物感染和乳腺癌的治疗剂的潜力.
- 需要进一步的研究来阐明这些有前途的化合物的精确作用机制.
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