相关实验视频
Updated: Jun 8, 2025

04:39
Generation of a Mouse Spontaneous Autoimmune Thyroiditis Model
Published on: March 17, 2023
1.6K
TSH受体抗体反应体有助于逆轨道炎症
Syed Morshed1,2, Maryam Mansoori1,2, Terry F Davies1,2
1Thyroid Research Unit, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Journal of the Endocrine Society
|November 6, 2024
概括
之前认为不活跃的中性TSHR抗体 (N-TSHR-mAbs) 可以在格雷夫斯病中引发显著的逆轨道炎症和细胞死亡. 这一发现扩大了我们对甲状腺眼病 (TED) 病原体的理解.
科学领域:
- 内分泌学 在内分泌学.
- 免疫学 免疫学 免疫学
- 眼科医生 眼科 眼科
背景情况:
- 格雷夫斯病通常涉及甲状腺眼病 (TED),其特点是逆轨道炎症和纤维细胞活动.
- 甲状腺刺激激素受体 (TSHR) 抗体与TED有关,但TSHR反应体包括具有不同活动的抗体.
- 中性TSHR抗体 (N-TSHR-mAbs) 在TED病变发生过程中的作用尚不清楚.
研究的目的:
- 研究针对TSHR链区域的N-TSHR-mAbs对纤维细胞的影响.
- 为了确定N-TSHR-mAbs是否可以促进TED中观察到的炎症过程.
主要方法:
- 对表达TSHR的纤维细胞暴露于特定的N-TSHR-mAb.
- 分析细胞压力,信号通路和细胞死亡机制.
- 评估炎酶激活,酶8和气皮素D.
主要成果:
- 在纤维细胞中,N-TSHR-mAb诱导了显著的细胞应激.
- 这种压力激活了炎性细胞信号通路.
- 这一过程的高潮是激素灭亡,一种编程细胞死亡的形式,由caspase 8和gasdermin D.介导.
结论:
- N-TSHR-mAbs可以在逆轨道纤维细胞中引起炎症反应和细胞死亡.
- 这些抗体可能会加剧甲状腺眼病 (TED) 中出现的炎症.
- TSHR反应体的多样化抗体活动有助于TED病原体的产生,而不仅仅是刺激抗体.
相关概念视频
Synthesis and Regulation of Thyroid Hormones
4.2K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
4.2K
T Cell Types and Functions
954
When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
954
Receptor Downregulation in MVBs
2.0K
Multivesicular bodies (MVBs) are mature endosomes that sort ubiquitinated proteins and then fuse with lysosomes to degrade the sorted proteins. Epidermal growth factor (EGF) and its receptor (EGFR) form a complex that can be internalized through endocytosis, sorted into an MVB, and later degraded.
The EGFR can initiate signaling pathways that lead to cell proliferation, migration, and differentiation. Overexpression of EGFR stimulates cells to proliferate. Excessive EGFR...
The EGFR can initiate signaling pathways that lead to cell proliferation, migration, and differentiation. Overexpression of EGFR stimulates cells to proliferate. Excessive EGFR...
2.0K
Diversity of Antigen Receptors
527
Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
527
Enzyme-linked Receptors
77.4K
Enzyme-linked receptors are proteins that act as both receptor and enzyme, activating multiple intracellular signals. This is a large group of receptors that include the receptor tyrosine kinase (RTK) family. Many growth factors and hormones bind to and activate the RTKs.
Neurotrophin (NT) receptors are a family of RTKs, including trkA, trkB, and trkC (tropomyosin-related kinase) receptors. TrkA is specific for nerve growth factor (NGF), neurotrophin-6, and neurotrophin-7. TrkB binds...
Neurotrophin (NT) receptors are a family of RTKs, including trkA, trkB, and trkC (tropomyosin-related kinase) receptors. TrkA is specific for nerve growth factor (NGF), neurotrophin-6, and neurotrophin-7. TrkB binds...
77.4K

