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三乙烯增强巨细胞炎症和脂解,有助于脂肪组织功能障碍

Richard C Chang¹, Ryan Scott Whitlock¹, Erika Joloya¹

¹Department of Developmental and Cell Biology, University of California, Irvine, CA 92697-2300, USA.

Journal of the Endocrine Society

|November 6, 2024

概括

三聚丁 (TBT) 通过改变脂肪细胞并促进巨细胞的炎症引起肥胖. 这些影响可以在几代人中继承,影响代谢健康.

科学领域:

环境毒理学环境毒理学
内分泌学在内分泌学.
免疫学免疫学免疫学

背景情况:

三乙烯 (TBT) 是一种工业化学物质,已知具有肥胖原性作用.
妊娠期间的TBT暴露会导致跨代肥胖,影响后代的白色脂肪组织.
结核病治疗对脂肪组织巨细胞及其在肥胖中的作用的影响仍然不清楚.

研究的目的:

为了研究TBT对巨细胞的影响.
为了确定TBT修饰的巨细胞对脂肪细胞功能的影响.
探索TBT对脂肪组织巨细胞和炎症的跨代影响.

主要方法:

主要来自小鼠骨髓的巨被用TBT治疗,并暴露于palmitate.
分析了炎症标志物的基因表达,有或没有PPARγ激活.
白色脂肪细胞从中介质层干细胞中分化出来,与用TBT治疗的巨细胞共同培养.
来自暴露于TBT和未暴露的世代的脂肪组织居民巨细胞被分析为炎症标志物.

主要成果:

TBT显著增强了巨细胞中棕酸盐诱导的炎症基因表达,这种效应被PPARγ激活减轻.
暴露于TBT的巨细胞减少了脂肪细胞中的脂质积累,并增加了脂解基因表达.
祖先的TBT暴露导致暴露 (F2) 和未暴露 (F3) 代的脂肪组织巨细胞中TNF表达的增加.

结论:

暴露于TBT会促进脂肪组织巨细胞的炎症.
TBT诱导的巨细胞功能障碍会损害脂肪细胞的功能,导致肥胖.
暴露于TBT会产生对炎症性脂肪组织巨细胞的遗传性倾向,从而影响代谢健康.

关键词:

在 PPARγγ 中.这是TBT的TBT.脂肪细胞的脂肪细胞.脂肪溶解是指脂质分解的过程.巨细胞是一个巨细胞.肥胖肥胖肥胖肥胖肥胖肥胖肥胖肥胖过氧体增殖器激活受体玛受体致敬林林的人民

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