与幼儿接触是老年人肺炎球菌殖民的主要风险因素
Anne L Wyllie1, Devyn Yolda-Carr1, Maikel S Hislop1
1Department of Epidemiology of Microbial Diseases, Yale School of Public Health, New Haven, CT 06510, United States.
肺炎球菌向老年人传播通常来自家庭内,特别是与儿童接触时. 肺炎球菌合疫苗 (PCV) 可以通过防止这种传播来保护老年人.
科学领域:
- 微生物学 微生物学
- 流行病学 流行病学
- 免疫学 免疫学 免疫学
背景情况:
- 对老年人肺炎球菌的传播尚未完全理解,这影响了肺炎球菌合疫苗 (PCV) 的有效性.
- 家庭传播被假设是肺炎球菌在非机构成年人中传播的主要途径.
研究的目的:
- 调查社区居住的老年人肺炎球菌传播的来源.
- 确定家庭接触和与儿童接触在老年人肺炎球菌携带中的作用.
主要方法:
- 一项纵向研究采用了年龄≥60岁的成年人,来自没有年轻居民的家庭.
- 唾液样本每两周收集一次,持续10周,并使用qPCR测试肺炎球菌.
- 通过社会和健康问卷,收集了有关潜在传播因素的数据,包括与儿童接触的数据.
主要成果:
- 总体而言,4.8%的样本和22.3%的个体显示出肺炎球菌殖民.
- 与儿童接触 (10.0%) 的人群中,肺炎球菌的携带率明显高于没有接触儿童的人群 (1.6%).
- 与幼儿接触是影响肺炎球菌感染的最重要因素.
结论:
- 家庭接触,特别是与幼儿接触,是肺炎球菌向老年人传播的关键因素.
- 肺炎球菌合疫苗 (PCV) 免疫接种为与儿童接触的老年人提供直接保护.
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