与结核病后的后果相关的危险因素:系统性审查和元分析
Temesgen Yihunie Akalu1,2,3, Archie C A Clements2,4, Alemneh Mekuriaw Liyew1,2,3
1School of Population Health, Faculty of Health Sciences, Curtin University, Perth, Western Australia, Australia.
EClinicalMedicine
|November 6, 2024
概括
鉴定结核病 (TB) 后遗症的危险因素对于改善结核病幸存者的结果至关重要. 这份综述强调年龄,吸烟,酒精和先前的结核病治疗是肺部和肝脏并发症的关键风险因素.
科学领域:
- 医学研究 医学研究
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 结核病 (TB) 后遗症给幸存者带来了重大挑战,影响了生活质量.
- 识别这些长期物理问题的风险因素对于有效管理至关重要.
研究的目的:
- 系统地审查和元分析与结核病幸存者的长期身体后果相关的风险因素.
- 量化各种因素与结核病后呼吸道,肝脏和听力障碍之间的关联.
主要方法:
- 在Medline,Embase,PROQUEST和Scopus数据库进行系统搜索,截至2023年12月12日.
- 包括73篇文章 (31,553名患者) 用于叙事综合和64篇用于元分析.
- 利用随机效应的元分析,并提出了几率比率 (OR) 和95%置信区间 (CI) 的发现.
主要成果:
- 结核病后肺部病变的危险因素包括年龄较大,以前的结核病治疗,吸烟,饮酒,涂抹阳性结核病和放射性病变.
- 结核病后肝损伤的危险因素包括先前存在的肝炎,先前的结核病治疗,低白蛋白血症和HIV同时感染.
- 结核病后听力损失的危险因素包括基线听力问题和艾滋病毒同时感染.
结论:
- 结核病后的长期身体后果与社会人口,行为和临床因素有关.
- 识别这些风险因素可以指导干预措施,以减轻后结核病后续的负担.
相关概念视频
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